sVCAM-1 expressions in cultured HUVECs under different doses of IgA1 treatment for different time durations.a. HUVECs were treated with 25-400 ug/ml IgA1 for 48 hours. IgA1 induced the sVCAM-1 expression in cultured HUVECs supernatant in a dose-dependent manner. Significantly increased supernatant sVCAM-1 level could be detected at 200 ug/ml and 400 ug/ml IgA1 (p=0.047 for 200 ug/ml, p<0.001 for 400 ug/ml).b. HUVECs were treated with 200 ug/ml IgA1 for 6–48 hours. IgA1 induced the sVCAM-1 expression in cultured HUVECs supernatant in a time-dependent manner. The sVCAM-1 level in HUVECs supernatant significantly elevated upon 48 h treatment (p=0.009).
Zhu et al. BMC Nephrology 2013 14:21 doi:10.1186/1471-2369-14-21