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Open Access Highly Accessed Research article

Effect of ferric carboxymaltose on serum phosphate and C-terminal FGF23 levels in non-dialysis chronic kidney disease patients: post-hoc analysis of a prospective study

Merche Prats13*, Ramon Font1, Carmen García1, Carmen Cabré1, Manel Jariod2 and Alberto Martinez Vea1

Author Affiliations

1 Nephrology Service.Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain

2 Unidad de Sistemas de Información de la Gestión, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain

3 Servicio de Nefrología, Hospital Universitari de Tarragona Joan XXIII, Carrer del Doctor Mallafré Guasch 4, 43007, Tarragona, Spain

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BMC Nephrology 2013, 14:167  doi:10.1186/1471-2369-14-167

Published: 31 July 2013

Abstract

Background

Some parenteral iron therapies have been found to be associated with hypophosphatemia. The mechanism of the decrease in serum phosphate is unknown. The aim of this study is to examine the effect of IV ferric carboxymaltose(FCM) on phosphate metabolism and FGF23 levels in patients with chronic kidney disease(CKD).

Methods

This is a post-hoc analysis of a prospective study carried out in 47 non-dialysis CKD patients with iron-deficiency anaemia who received a single 1000 mg injection of FCM. Markers of mineral metabolism (calcium, phosphate, 1,25-dihydroxyvitamin D, PTH and FGF23[c-terminal]) were measured prior to FCM administration and at week 3 and week 12 after FCM administration. Based on the measured levels of serum phosphate at week 3, patiens were classified as hypophosphatemic or non-hypophosphatemic.

Results

Serum phosphate levels decreased significantly three weeks after FCM administration and remained at lower levels at week 12 (4.24 ± 0.84 vs 3.69 ± 1.10 vs 3.83 ± 0.68 mg/dL, respectively, p < 0.0001. Serum calcium, PTH and 1,25-dihydroxyvitamin D did not change over the course of the study. Serum FGF23 decreased significantly from 442(44.9-4079.2) at baseline to 340(68.5-2603.3) at week 3 and 191.6(51.3-2465.9) RU/mL at week 12, p < 0.0001. Twelve patients were non-hypophosphatemic and 35 hypophosphatemic. FGF23 levels decreased in both groups, whereas no changes were documented in any of the other mineral parameters.

Conclusions

In non-dialysis CKD patients, FCM induces reduction in serum phosphate levels that persists for three months. FCM causes a significant decrease in FGF23 levels without changes to other bone metabolism parameters.

Keywords:
Chronic kidney disease; Ferric carboxymaltose; Fibroblast growth factor 23; Hypophosphatemia; Iron deficiency anaemia