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Open Access Highly Accessed Case report

Splanchnic vein thrombosis following renal transplantation: a case report

Erhan Tatar1*, Adam Uslu2, Ahmet Aykas2, Funda Tasli3, Ozgur Oztekin4 and Gulsum Akgun Cagliyan5

Author Affiliations

1 Department of Nephrology and Transplantation Center, Izmir Education and Research Hospital, Izmir, Turkey

2 Department of General Surgery and Transplantation Center, Izmir Education and Research Hospital, Izmir, Turkey

3 Department of Pathology, Izmir Education and Research Hospital, Izmir, Turkey

4 Department of Radiology, Izmir Education and Research Hospital, Izmir, Turkey

5 Department of Hematology, Izmir Education and Research Hospital, Izmir, Turkey

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BMC Nephrology 2013, 14:161  doi:10.1186/1471-2369-14-161

Published: 22 July 2013

Abstract

Background

Recurrent episodes of venous thrombosis have been closely correlated with JAK2 V617F mutation. Upto date, JAK2 gene mutation has not been defined as a prothrombic risk factor in renal transplant recipients. Herein; we present a case of portosplenic vein thrombosis in a primary renal transplant recipient with JAK2 V617F mutation who had no history of prior venous thromboembolism or thrombophilia.

Case presentation

A 59 year old female caucasian patient with primary kidney transplant admitted with vague abdominal pain at left upper quadrant. Abdominal doppler ultrasound and magnetic resonance imaging angiography demonstrated splanchnic vein thrombosis (SVT). The final diagnosis was SVT due to MPD (essential thrombocytosis, ET) with JAK2 V617F mutation. After 3 months of treatment with warfarin (≥5 mg/day, to keep target INR values of 1.9-2.5), control MRI angiography and doppler USG demonstrated partial (>%50) resolution of thrombosis with recanalization of hepatopedal venous flow. The patient is still on the same treatment protocol without any complication.

Conclusion

JAK2 V617F mutation analysis should be a routine procedure in the diagnosis and treatment of kidney transplant patients with thrombosis in uncommon sites.

Keywords:
Thrombosis; Portosplenic vein thrombosis; JAK2 gene mutation; Myeloproliferative disorders; Renal transplantation