Table 2

Results of Cox’s proportional hazards analysis of clinical parameters and all-cause mortality
Univariate analysis Multivariate analysis in a stepwise procedure
Beta coefficient unadjusted HR 95%CI P value Beta coefficient adjusted HR 95%CI P value
Age ≥65 years 0.972 2.643 1.425–4.900 0.002** 0.674 1.961 1.017–3.781 0.044*
Male −0.003 0.997 0.560–1.776 0.992
Current smoker 0.190 1.210 0.544–2.689 0.648
Duration of HD ≥10 years −0.068 0.934 0.520–1.677 0.819
Systolic BP <110 mmHg 0.721 2.057 0.759–5.575 0.156
110–140 mmHg - - - -
≥140 mmHg 0.158 1.171 0.641–2.140 1.171
Hemoglobin <10 g/dL 0.006 1.006 0.554–1.826 0.984
10–11 g/dL - - - -
≥11 g/dL 0.569 1.767 0.681–4.589 0.242
White blood cells ≥10000/mm3 −0.112 0.894 0.123–6.472 0.911
Platelet ≥35 × 104/μL 0.330 0.719 0.175–2.959 0.648
hs-CRP ≥3 mg/L 0.957 2.604 1.490–4.552 0.001**
Albumin <3.5 g/dL 1.016 2.761 1.580–4.828 <0.001** 0.788 2.198 1.218–3.968 0.012*
Potassium ≥5.5 mEq/L 0.128 1.136 0.484–2.667 0.769
Phosphate ≥6 mg/dL −0.211 0.810 0.322–2.041 0.655
Total Cholesterol ≥200 mg/dL 0.123 1.130 0.508–2.513 0.764
DN 0.300 1.349 0.772–2.359 0.293
History of CVD 1.045 2.844 1.615–5.009 <0.001** 0.727 2.068 1.146–3.732 0.016*
Plasma S100A12 levels ≥18.79 ng/mL 0.967 2.631 1.419–4.878 0.002** 0.919 2.267 1.195–4.302 0.012*

HD = hemodialysis, BP = blood pressure, hs-CRP = high-sensitivity C-reactive protein, DN = diabetic nephropathy, CVD = cardiovascular disease,

HR = hazard ratio, 95%CI = 95% confidence interval.

**P < 0.01, *P < 0.05.

Shiotsu et al.

Shiotsu et al. BMC Nephrology 2013 14:16   doi:10.1186/1471-2369-14-16

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