Table 1

Clinical characteristics and plasma S100A12 levels in the development population
All (n = 550) Died (n = 50) Survived (n = 500) P valuea
Age (years) 63.4 ± 12.1b 69.9 ± 10.1 62.8 ± 12.1 <0.001**
Male/Female (n) 355/195 32/18 323/177 0.933
Current smoker/nonsmoker (n) 65/485 7/43 58/442 0.616
Duration of HD (years) 9.7 ± 8.4 9.7 ± 8.8 9.7 ± 8.3 0.969
Systolic BP (mmHg) 143.4 ± 26.0 143.4 ± 26.0 142.9 ± 22.0 0.878
Hemoglobin (g/dL) 10.3 ± 1.1 10.4 ± 1.2 10.3 ± 1.1 0.589
White blood cells (/mm3) 5729 ± 1816 5814 ± 1554 5720 ± 1841 0.728
Platelet (104/μL) 16.8 ± 5.9 16.1 ± 6.0 16.8 ± 5.9 0.398
hs-CRP (mg/L) 1.0 (0.4–3.0)c 2.1 (0.8–6.3) 0.9 (0.4–2.7) <0.001**
Creatinine (mg/dL) 10.5 ± 2.6 9.6 ± 2.8 10.6 ± 2.6 0.010*
Albumin (g/dL) 3.7 ± 0.4 3.5 ± 0.4 3.7 ± 0.4 <0.001**
Sodium (mEq/L) 139.5 ± 3.0 138.4 ± 3.0 139.6 ± 2.9 0.003**
Potassium (mEq/L) 4.6 ± 0.7 4.4 ± 0.8 4.6 ± 0.7 0.175
Adjusted calcium (mg/dL) 9.3 ± 0.6 9.2 ± 0.6 9.3 ± 0.6 0.380
Phosphate (mg/dL) 4.7 ± 1.1 4.5 ± 1.2 4.7 ± 1.1 0.283
Calcium (mg/dL) × Phosphate (mg/dL) 41.5 ± 10.5 39.0 ± 10.4 41.8 ± 10.5 0.074
Total cholesterol (mg/dL) 162.3 ± 45.8 158.4 ± 43.2 162.7 ± 46.1 0.534
DN/nonDN (n) 202/348 22/28 180/320 0.263
History of CVD/no history of CVD (n) 197/353 30/20 167/333 <0.001**
Plasma S100A12 levels (ng/mL) 18.79 (11.70–30.37)c 25.10 (16.21–47.64) 17.93 (11.16–29.28) 0.001**

a Died versus survived. bMeans ± SD (all such values). cMedian value; 25%–75% value shown in parentheses (all such values). HD = hemodialysis, BP = blood pressure, hs-CRP = high-sensitivity C-reactive protein, DN = diabetic nephropathy, CVD = cardiovascular disease.

*P < 0.05, **P < 0.01.

Shiotsu et al.

Shiotsu et al. BMC Nephrology 2013 14:16   doi:10.1186/1471-2369-14-16

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