Table 3

Relative hazards (95% CI) forall-causemortality by solute
Solute Overall (continuous, per 1 SD) Hazard ratio (95% CI)
Below median Above median
P-cresol sulfate
Range of values 0-11.1 mg/dl (SD = 1.76 mg/dl) 0-3.1 mg/dl 3.1-11.1 mg/dl
Unadjusted 1.05 (0.93-1.17) Reference 1.10 (0.88-1.37)
Adjusted* 1.02 (0.90-1.16) Reference 1.03 (0.81-1.31)
+ obesity, creatinine 1.02 (0.90-1.16) Reference 1.03 (0.83-1.28)
Indoxyl sulfate
Range of values 0-6.8 mg/dl (SD = 1.11 mg/dl) 0-1.6 mg/dl 1.6-6.8 mg/dl
Unadjusted 0.93 (0.84-1.04) Reference 1.03 (0.83-1.28)
Adjusted* 0.98 (0.87-1.10) Reference 1.14 (0.90-1.44)
+ obesity, creatinine 1.04 (0.91-1.18) Reference 1.30 (1.01-1.69)
MMA
Range of values 24.2-190.6 ug/L (SD = 16.48 ug/L) 24.2-49.6 ug/L 49.7-190.6 ug/L
Unadjusted 1.10 (0.99-1.23) Reference 1.01 (0.81-1.26)
Adjusted* 1.05 (0.94-1.17) Reference 0.94 (0.74-1.20)
+ obesity, creatinine 1.09 (0.97-1.22) Reference 1.00 (0.78-1.29)
DMA
Range of values 7.6-33.9 uM (SD = 3.69 uM) 7.6-18.3 uM 18.3-33.9 uM
Unadjusted 0.96 (0.86-1.07) Reference 0.86 (0.69-1.08)
Adjusted* 1.00 (0.89-1.12) Reference 0.88 (0.69-1.11)
+ obesity, creatinine 1.01 (0.90-1.14) Reference 0.91 (0.71-1.17)
Total Score (vs. 0)** Continuous 1 2 3 4
Unadjusted 1.00 (0.91-1.09) 1.53 (1.03-2.27) 1.24 (0.87-1.77) 1.21 (0.83-1.77) 1.14 (0.72-1.79)
Adjusted* 0.99 (0.89-1.10) 1.28 (0.85-1.94) 1.24 (0.85-1.80) 0.96 (0.64-1.43) 1.26 (0.78-2.04)
+ obesity, creatinine 1.04 (0.93-1.16) 1.29 (0.84-1.99) 1.28 (0.86-1.90) 1.06 (0.69-1.64) 1.49 (0.88-2.51)

All models stratified by clinic cluster. *Adjustment: basic model, age at enrollment, sex, race, comorbidity score (ICED), and baseline albumin: + obesity and creatinine value. **Total number of solutes with levels above the population median.

Melamed et al.

Melamed et al. BMC Nephrology 2013 14:134   doi:10.1186/1471-2369-14-134

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