Email updates

Keep up to date with the latest news and content from BMC Nephrology and BioMed Central.

Open Access Research article

Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease

Po-Chao Hsu15, Suh-Hang Juo367, Ho-Ming Su148, Szu-Chia Chen28, Wei-chung Tsai1, Wen-Ter Lai14, Sheng-Hsiung Sheu14 and Tsung-Hsien Lin14*

Author Affiliations

1 Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC

2 Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC

3 Department of Medical Research, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC

4 Faculty of Medicine, Kaohsiung, Taiwan

5 Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

6 Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan

7 Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

8 Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan

For all author emails, please log on.

BMC Nephrology 2012, 13:98  doi:10.1186/1471-2369-13-98

Published: 30 August 2012

Abstract

Background

Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events. Chronic kidney disease (CKD) is associated with poor coronary collateral development and cardiovascular outcome. However, limited research investigates the predictors for collateral development in the CKD population.

Methods

We evaluated 970 consecutive patients undergoing coronary angiography and 202 patients with CKD, defined as a glomerular filtration rate less than 60 ml/min/1.73 m2, were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patients into poor (grades 0 and 1) or good (grades 2 and 3) collateral group.

Results

The patients with poor collateral (n = 122) had a higher incidence of hypertension (82% vs 63.8%, p = 0.005), fewer diseased vessels numbers (2.1 ± 0.9 vs 2.6 ± 0.6, p < 0.001) and a trend to be diabetic (56.6% vs. 43.8%, p = 0.085) or female sex (37.7% vs. 25.0%, p = 0.067). Multivariate analysis showed hypertension (odd ratio (OR) 2.672, p = 0.006), diabetes (OR 1.956, p = 0.039) and diseased vessels numbers (OR 0.402, p < 0.001) were significant predictors of poor coronary collaterals development. Furthermore, hypertension and diabetes have a negative synergistic effect on collateral development (p = 0.004 for interaction).

Conclusions

In the CKD population hypertension and diabetes might negatively influence the coronary collaterals development.

Keywords:
Chronic kidney disease; Coronary artery disease; Coronary collateral circulation, Hypertension, Diabetes