Open Access Research article

Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study

Hayne Cho Park12, Jin Ho Hwang1, Ah-Young Kang3, Han Ro4, Myung-Gyu Kim3, Jung Nam An1, Ji In Park1, Seung Hyup Kim5, Jaeseok Yang3, Yun Kyu Oh1, Kook-Hwan Oh1, Jung Woo Noh6, Hae Il Cheong278, Young-Hwan Hwang19* and Curie Ahn1238*

Author Affiliations

1 Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-Ro Jongno-Gu, Seoul, 110-744, South Korea

2 Research Center for Rare Diseases, Seoul National University Hospital, Seoul, South Korea

3 Transplantation Center, Seoul National University Hospital, Seoul, South Korea

4 Department of Internal Medicine, Gacheon University Gil Hospital, Incheon, South Korea

5 Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea

6 Department of Internal Medicine, Hallym University College of Medicine, Seoul, South Korea

7 Department of Pediatrics and Adolescent Medicine, Seoul National University College of Medicine, Seoul, South Korea

8 Kidney Research Institute, Seoul National University Hospital, Seoul, South Korea

9 Department of Internal Medicine, Eulji General Hospital, Eulji University 280-1 Hagye 1-dong, Nowon-gu, Seoul, 139-711, Korea

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BMC Nephrology 2012, 13:93  doi:10.1186/1471-2369-13-93

Published: 30 August 2012

Additional files

Additional file 1:

Patient distribution according to chronic kidney disease stages. The proportion of advanced CKD stages (IIIB and IV) increased as time passed.

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Additional file 2:

Linear regression analysis between the estimated glomerular filtration rate and total kidney volume. The TKV was negatively correlated with the estimated GFR (r2 = 0.334, P < 0.001).

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Additional file 3:

Urinary NAG/Cr according to chronic kidney disease stages. Patients in chronic kidney disease (CKD) stage III (estimated GFR < 60 mL/min/1.73 m2) showed significantly higher urinary NAG/Cr compared with CKD stage I or II (6.48 ± 3.79 vs. 3.7 ± 2.13 vs. 4.67 ± 2.47, P < 0.001).

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Additional file 4:

Repeated measurements of NAG/Cr could not predict renal function deterioration in 1 year. The patients were divided into three groups according to serial measurements of urinary NAG/Cr: persistently low NAG/Cr (<4.95 IU/g) (Group L-L), variable NAG/Cr (Group V), and persistently high NAG/Cr (≥4.95 IU/g) (Group H-H). Group H-H showed lower estimated GFRs at baseline (64.5 ± 23.3 mL/min/1.73 m2) and lower estimated GFR at 12 month (50.3 ± 18.5 mL/min/1.73 m2) compared to other groups (P < 0.001). Although statistically insignificant, the percentage decrement of estimated GFR over 12 months were greater in Group H-H compared to the other groups (Group H-H vs. Group V vs. Group L-L, -23.0% vs. -20.8% vs. -21.2%, P = 0.77).

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