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Open Access Case report

A case of rapidly progressive IgA nephropathy in a patient with exacerbation of Crohn’s disease

Ji-Young Choi1, Chung Hoon Yu1, Hee-Yeon Jung1, Min Kyu Jung2, Yong-Jin Kim3, Jang-Hee Cho1, Chan-Duck Kim1, Yong-Lim Kim1 and Sun-Hee Park1*

Author Affiliations

1 Division of Nephrology, Department of Internal Medicine, Kyungpook National University School of Medicine and Clinical Research Center for End Stage Renal Disease in Korea, 130 Dongduk-ro, Jung-gu, Daegu, South Korea

2 Division of Gastroenterology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea

3 Department of Pathology, Yeungnam University School of Medicine, Daegu, South Korea

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BMC Nephrology 2012, 13:84  doi:10.1186/1471-2369-13-84

Published: 6 August 2012

Abstract

Background

IgA nephropathy has been reported as a renal involvement in Crohn’s disease. Crescentic IgA nephropathy, which accounts for fewer than 5% of cases of IgA nephropathy, has a poorer prognosis than other forms of crescentic glomerulonephritis. We recently experienced a case of rapidly progressive IgA nephropathy concurrent with exacerbation of Crohn’s disease.

Case presentation

An 18-year-old male diagnosed with Crohn’s disease underwent a hemicolectomy 2 years prior previously. He had maintained a state of Crohn’s disease remission with 5-aminosalicylic acid treatment. Four months prior to referral to the nephrology clinic, he experienced non-bloody diarrhea. He simultaneously developed proteinuria and microscopic hematuria with deterioration of renal function. Based on renal biopsy findings, the patient was diagnosed with crescentic IgA nephropathy. Immunostaining for interleukin-17 in renal tissue and previous exacerbated colonic ulcers was positive. Steroid pulse therapy was administered, followed by high-dose glucocorticoid and oral cyclophosphamide therapy. The patient’s renal function recovered and his gastrointestinal symptoms were alleviated.

Conclusions

We report a case of crescentic IgA nephropathy presenting with exacerbation of Crohn’s disease, and present a review of the literature focusing on the pathophysiologic relationship between these two conditions.

Keywords:
Rapidly progressive IgA nephropathy; Crohn’s disease