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Unexpected outcome after sclerotherapy of simple renal cyst

Yasuhiro Hashimoto12*, Atsushi Imai1, Noriko Tokui1, Atsushi Sasaki1, Hisao Saitoh1, Takuya Koie2 and Chikara Ohyama2

Author Affiliations

1 Oyokyo Kidney Research Institute Hirosaki Hospital, 90 Yamazaki Kozawa, Hirosaki, Aomori 036-8243, Japan

2 Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, Aomori 036-8562, Japan

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BMC Nephrology 2012, 13:63  doi:10.1186/1471-2369-13-63

Published: 24 July 2012



Simple renal cysts usually have benign clinical features. We report a rare case of papillary renal cell carcinoma (RCC) associated with a large recurrent simple cyst following sclerotherapy.

Case Presentation

A 47-year-old Japanese woman received minocycline sclerotherapy for a large (9 cm in diameter) simple left renal cyst in May 2005. The cyst regrew, and second-line sclerotherapy with ethanol was performed in November 2005. Three years later, she developed papillary RCC on the wall of the recurrent renal cyst. Radical nephrectomy was performed, but the patient died of metastatic disease 15 months after surgery.


Malignant transformation from recurrent simple renal cyst to RCC may occur in the years following sclerotherapy, underscoring the need for long-term follow-up.

Papillary renal cell carcinoma; Simple renal cyst; Sclerotherapy; Malignant transformation