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Open Access Case report

A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood

Kenji Tsuji1, Haruhito Adam Uchida1*, Tetsuichirou Ono1, Tatsuyuki Inoue1, Katsuji Shinagawa2, Shinji Kitamura1, Yohei Maeshima1, Hitoshi Sugiyama1 and Hirofumi Makino1

Author Affiliations

1 Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, kita-ku 700-8558, Japan

2 Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, kita-ku, 700-8558, Japan

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BMC Nephrology 2012, 13:46  doi:10.1186/1471-2369-13-46

Published: 24 June 2012

Abstract

Background

Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause.

Case presentation

We report a 36-year-old man who had suffered membranoproliferative glomerulonephritis (MPGN) in his childhood, later diagnosed with CVID at 35 years of age. He presented at our hospital with signs of proteinuria. A renal biopsy revealed he suffered from focal segmental glomerulosclerosis (FSGS), possibly due to obesity and hypertension, not CVID - associated MPGN.

Conclusion

This is the first case report of FSGS in a CVID patient. In this case, we have to pay attention not only to the treatment of obesity and hypertension for FSGS but also to the recurrence of immune-complex glomerulonephritis such as MPGN, in case of the restoration of hypogammaglobulinemia.

Keywords:
Hypogammaglobulinemia; Focal segmental glomerulosclerosis; Proteinuria