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Open Access Research article

Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample

Kathleen Dittmann1*, Henri Wallaschofski1, Rainer Rettig2, Sylvia Stracke3, Karlhans Endlich4, Henry Völzke5, Matthias Nauck1 and Nele Friedrich1

Author affiliations

1 Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany

2 Institute of Physiology, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany

3 Department of Internal Medicine A, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany

4 Institute of Anatomy and Cell Biology, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany

5 Institute for Community Medicine, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany

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Citation and License

BMC Nephrology 2012, 13:169  doi:10.1186/1471-2369-13-169

Published: 13 December 2012

Abstract

Background

Insulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study among US adults. The aim of the present study was to investigate whether serum IGF-I or IGFBP-3 are associated with estimated glomerular filtration rate (eGFR) in a population-based study of Caucasian adults.

Methods

Data from 4028 subjects (2048 women) aged 20 to 81 years from the Study of Health in Pomerania (SHIP) were analyzed. Total serum IGF-I and IGFBP-3 concentrations were determined by chemiluminescence immunoassays and categorized into sex- and age-specific quartiles.

Results

After adjusting for age, waist circumference and type 2 diabetes mellitus, analysis of variance (ANOVA) revealed inverse associations between serum IGF-I concentrations and eGFR in men as well as between serum IGFBP-3 concentrations and eGFR in men and women. Logistic regression analyses confirmed these findings and showed that high IGF-I or IGFBP-3 concentrations were associated with an increased risk of decreased eGFR (<60 mL/min/1.73 m2) in men or women. These relations became stronger when lower eGFR cut-offs were used for the analyses.

Conclusion

Our data revealed associations of increased serum IGF-I concentrations and decreased eGFR in men but not in women and an association of increased serum IGFBP-3 concentrations and decreased eGFR in both sexes.

Keywords:
eGFR; Insulin-like growth factor; IGF-I; IGFBP-3; Renal function; Study of health in Pomerania