Urine volume (Panel A), urinary Na excretion (Panel B) and creatinine clearance (Panel C) in control and Pax8-rtTA/LC1/floxed ETA (iETA) mice before and after doxycycline (DOX) treatment. Animals were fed a normal (0.3%) Na diet for 3 days followed by a high (3.2%) Na diet for 7 days. Urine (24 hr) was obtained on the third day of starting normal or high Na diets. Note that within each panel, open or closed bars represent the same mice, i.e., mice were sequentially given a normal and high Na diet, treated with DOX, and the diets repeated. N = 8 each data point.
Stuart et al. BMC Nephrology 2012 13:166 doi:10.1186/1471-2369-13-166