Table 3

Incidence of dementia estimatedby comorbidity for CKDand non-CKD cohorts
Non-CKD CKD
Comorbidity Case Incidence rate Case Incidence rate HR (95% CI)
Hypertension
No 995 3.01 337 3.48 1.64 (1.45-1.86)
Yes 1626 11.5 1676 14.02 1.48 (1.38-1.58)
Diabetes mellitus
No 2212 5.08 1203 7.83 1.52 (1.42-1.64)
Yes 409 11.2 810 12.9 1.42 (1.26-1.60)
Ischemic heart disease
No 1680 4.23 921 6.05 1.63 (1.50-1.76)
Yes 941 12.5 1092 17.0 1.52 (1.39-1.65)
Hyperlipidemia
No 2286 5.33 1491 9.36 1.65 (1.54-1.78)
Yes 335 7.78 522 9.14 1.43 (1.25-1.64)
Tobacco use disorder
No 2620 5.55 2007 9.30 1.60 (1.51-1.70)
Yes 1 1.81 6 11.1 6.73 (0.81-56.1)
Alcoholism
No 2608 5.54 1992 9.27 1.60 (1.50-1.69)
Yes 13 8.72 21 14.8 2.88 (1.41-5.91)
Obesity
No 2614 5.56 2001 9.34 1.60 (1.51-1.70)
Yes 7 3.13 12 5.32 2.81 (1.04-7.58)
Atrial fibrillation
No 2562 5.46 1929 9.03 1.59 (1.50-1.69)
Yes 59 19.2 84 29.9 1.67 (1.19-2.33)
Parkinson's disease
No 2482 5.30 1876 8.78 1.61 (1.51-1.71)
Yes 139 38.0 137 50.9 1.30 (1.02-1.65)
Cerebrovascular disease
No 1701 4.01 1048 5.89 1.59 (1.47-1.72)
Yea 920 19.2 965 25.1 1.41 (1.28-1.54)
Major depressive disorder
No 2546 5.44 1949 9.15 1.61 (1.51-1.71)
Yes 75 16.5 64 18.8 1.44 (1.03-2.03)

Incidence rate: per 1,000 person-years.

HR: CKD vs. non-CKD (95% CI), adjsued for age, sex, use of benzodiazepine, aspirin, other NSAIDs and COX2.

Cheng et al.

Cheng et al. BMC Nephrology 2012 13:129   doi:10.1186/1471-2369-13-129

Open Data