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Open Access Research article

Peripheral artery disease in peritoneal dialysis and hemodialysis patients: single-center retrospective study in Taiwan

Chun-Chuan Lee1, Chih-Jen Wu24, Li-Hua Chou3, Su-Mei Shen3, Sheng-Fang Chiang3, Pi-Chu Jen3, Mei-Ching Yeh3 and Chi-Feng Pan25*

Author Affiliations

1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan

2 Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan

3 Division of Hemodialysis and Peritoneal Dialysis, Department of Nursing, Mackay Memorial Hospital, Taipei, Taiwan

4 College of Medicine, Taipei Medical University, Taipei, Taiwan

5 Mackay Medicine, Nursing and Management College, Taipei, Taiwan

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BMC Nephrology 2012, 13:100  doi:10.1186/1471-2369-13-100

Published: 3 September 2012

Abstract

Background

Peripheral artery disease (PAD) is a condition characterized by restricted blood flow to the extremities, and is especially common in the elderly. PAD increases the risk for mortality and morbidity in patients with end-stage renal disease (ESRD), especially those on hemodialysis (HD).

Methods

The records of 484 patients with end-stage renal disease who were on HD or peritoneal dialysis (PD) were reviewed. PAD was diagnosed based on the ankle-brachial pressure index (ABI). Demographic and clinical characteristics were analyzed.

Results

PAD had an overall prevalence of 18.2% and was significantly more common in HD patients (21.8%) than in PD patients (4.8%). Advanced age, diabetes mellitus, smoking, low parathyroid hormone level, elevated serum ferritin, elevated serum glucose, and low serum creatinine levels increased the risk for PAD. PAD was independently associated with advanced age, diabetes mellitus, duration of dialysis, low serum creatinine, and hyperlipidemia. PD patients had a significantly lower prevalence of PAD than HD patients, maybe due to their younger age and lower prevalence of diabetes mellitus in this present study.

Conclusions

The prevalence of PAD was greater in the HD group than the PD group. Most of the risk factors for PAD were specific to HD, and no analyzed factor was significantly associated with PAD in PD patients.

Keywords:
Ankle-brachial pressure index (ABI); Cardiovascular disease; End-stage renal disease; Hemodialysis; Peritoneal dialysis; Peripheral artery disease