Figure 1.

Renal health evaluation of PKD2 mutant rats at different time points after birth. (A) Total kidney weight (g) of three wild-type (SD) and three mutant rats (PKD2 Mut) for each time-point (0-60 days after birth). Values are means of total kidney weight +/- SEM. (B) Kidney to body weight ratio (%) of three wild-type (SD) and three mutant rats (PKD2 Mut) for each time-point (0, 12, 24, 36, 48 and 60 days after birth). Values represent the mean of total kidney weight +/- SEM, * indicates statistical significance at p < 0.05. (C) Serum urea levels (mg/dl) of three wild-type (SD) and three mutant rats (PKD2 Mut) for each time-point (0-60 days after birth). Serum urea levels could not be determined at 0 days for either SD or PKD2 Mut rats (ND). Values are means of total kidney weight +/- SEM. (D) Serum creatinine levels (mg/dl) of three wild-type (SD) and three mutant rats (PKD2 Mut) for each time-point (0, 12, 24, 36, 48 and 60 days after birth). Serum creatinine levels could not be determined at 0 days for either SD or PKD2 Mut rats (ND). Values represent the mean of total kidney weight +/- SEM.