Distribution of rates of change of serum creatinine (ΔSCr/Δtwait) while awaiting orthotopic liver transplantation (OLT) in patients who did or did not develop post-OLT acute kidney injury (AKI). Patients were stratified in order to according to ΔSCr/Δtwait and subdivided into deciles containing equal numbers of patients. ΔSCr/Δtwait was defined as the absolute change of serum creatine (ΔSCr) while awaiting OLT (SCr pre-OLT minus SCr at registration) divided by the time awaiting OLT. The percentage of the total number of patients (n = 243) who developed AKI (AKI) falling within each decile is plotted. Similarly, the percentage of the total number of patients (n = 445) who did not develop AKI (NO AKI) within each decile is plotted. Negative values of ΔSCr/Δtwait correspond to improved renal function, while positive values of ΔSCr/Δtwait correspond to worsened renal function. The inverse relationship between degree of renal functional improvement and risk for AKI was statistically significant (p = 0.008).
Iglesias et al. BMC Nephrology 2010 11:30 doi:10.1186/1471-2369-11-30