Risk factors for chronic kidney disease in Japan: a community-based study

doi:10.1186/1471-2369-10-34

BMC Nephrology
Volume 10

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Takamatsu N
Abe H
Tominaga T
Nakahara K
Ito Y
Okumoto Y
Kim J
Kitakaze M
Doi T

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Abe H
Tominaga T
Nakahara K
Ito Y
Okumoto Y
Kim J
Kitakaze M
Doi T
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Research article

Risk factors for chronic kidney disease in Japan: a community-based study

Norimichi Takamatsu^*¹ , Hideharu Abe^*¹ , Tatsuya Tominaga^*¹ , Kunihiko Nakahara^*² , Yumi Ito^*² , Yoko Okumoto^*³ , Jiyoong Kim^*⁴ , Masafumi Kitakaze^*⁴ and Toshio Doi¹

¹Department of Clinical Biology and Medicine, Graduate School of Medicine, Institute of Health-Bio-Science, University of Tokushima, Tokushima, Japan

²Hubit Genomix Inc., Tokyo, Japan

³Arita-cho, Saga, Japan

⁴National Cardiovascular Center, Osaka, Japan

author email corresponding author email* Contributed equally

BMC Nephrology 2009, 10:34doi:10.1186/1471-2369-10-34


Published:	27 October 2009

Abstract

Background

Chronic kidney disease (CKD) is increasingly being recognized as a predictor for both end-stage renal disease and cardiovascular disease. The present study, conducted on individuals from a community in Arita, Japan, was designed to evaluate biomarkers that can be used to determine the associated factors for CKD.

Methods

This study involved 1554 individuals. Kidney function was evaluated in terms of the creatinine-based estimated glomerular filtration rate (eGFR), which was determined using the Modification of Diet in Renal Disease equation. Low eGFR was defined as eGFR < 60 mL/min per 1.73 m². The concentration of both urinary albumin and urinary type IV collagen were measured.

Results

In the younger participants (age, <65 years), the odds ratio (95% confidence interval [CI]) of low eGFR was 1.17 (1.02 to 1.34) for each 1 year older age, 6.28 (1.41 to 28.03) for urinary albumin creatinine ratio (ACR) over 17.9 mg/g and 9.43 (2.55 to 34.91) for hyperlipidemia. On the other hand, among the elderly participants (age, ≥ 65 years), the odds ratio (95% CI) of low eGFR was 2.97 (1.33 to 6.62) for gender, 1.62 (1.06 to 2.50) for hypertension and 1.97 (1.19 to 3.28) for hyperlipidemia. Urinary type IV collagen creatinine ratio was not identified as an associated factor for low eGFR.

Conclusion

In this present cross-sectional community-based study, ACR is associated with CKD, which was defined as an eGFR of less than 60 mL/min per 1.73 m², in the younger participants but not in the older participants.