|
Distribution of genotypes of the -2221 (C/T) insulin polymorphism in German patients with autoimmune endocrinopathies and healthy controls |
|||||||||||
| Genotype |
|||||||||||
|
|
|||||||||||
| CC |
CT |
TT |
Allele |
||||||||
|
|
|
|
|
||||||||
| Group |
n |
n |
% |
n |
% |
n |
% |
p* |
C% |
T% |
p* |
|
|
|||||||||||
| HC |
275 |
182 |
66.2 |
85 |
30.9 |
8 |
2.9 |
81.6 |
18.4 |
||
| T1D |
317 |
249 |
78.5 |
64 |
20.2 |
4 |
1.3 |
0.0027 |
88.6 |
11.4 |
8.9 × 10-4 |
| HT |
61 |
36 |
59.0 |
22 |
36.1 |
3 |
4.9 |
0.4898 |
77.0 |
23.0 |
0.2998 |
| AD |
107 |
73 |
68.2 |
25 |
23.4 |
9 |
8.4 |
0.0331† |
79.9 |
20.1 |
0.4738 |
| APS-II |
62 |
45 |
72.6 |
16 |
25.8 |
1 |
1.6 |
0.5870 |
85.5 |
14.5 |
0.3763 |
|
|
|||||||||||
| T1D + AIT |
22 |
18 |
81.8 |
4 |
18.2 |
0 |
0 |
0.2898 |
90.9 |
9.1 |
0.2898 |
| T1D + HT |
15 |
13 |
86.7 |
2 |
13.3 |
0 |
0 |
0.2479 |
93.3 |
6.7 |
0.1653 |
| T1D + GD |
7 |
5 |
71.4 |
2 |
28.6 |
0 |
0 |
0.8851 |
85.7 |
14.3 |
0.9682 |
| AD + AIT |
33 |
22 |
66.7 |
10 |
30.3 |
1 |
3.0 |
0.9968 |
81.8 |
18.2 |
0.8948 |
| AD + HT |
23 |
15 |
65.2 |
8 |
34.8 |
0 |
0 |
0.6790 |
82.6 |
17.4 |
0.9723 |
| AD + GD |
10 |
7 |
70.0 |
2 |
20.0 |
1 |
10 |
0.3802 |
80.0 |
20.0 |
0.9138 |
| T1D + AD + HT |
7 |
5 |
71.4 |
2 |
28.6 |
0 |
0.0 |
0.8851 |
85.7 |
14.3 |
0.9682 |
|
P values are given uncorrected *compared to healthy controls †Not significant after correction | |||||||||||
Ramos-Lopez et al. BMC Medical Genetics 2008 9:65 doi:10.1186/1471-2350-9-65 |
|||||||||||