Table 2

Loci exhibiting pairwise linkage disequilibrium at p <= 0.05. Bold-faced loci indicate a combination detected at the α = 0.05 level in an AD stratum but not in the corresponding control stratum. These multi-locus combinations were used as models in LR analyses.

Loci

D'

p-value

Loci

D'

p-value


AD males

lhcgr1/lhb1

0.576

0.029

Control males

lhcgr1/lhb3

1.000

0.019

lhcgr1/lhb5

0.388

0.020

lhcgr1/lhb5

0.494

0.033

lhcgr2/APOE

1.000

0.002a

lhcgr4/APOE

0.643

0.048

lhcgr5/lhb2

0.305

0.023

lhcgr5/APOE

0.746

0.047

lhcgr5/lhb4

0.293

0.033

lhcgr5/lhb5

0.335

0.028

AD females

lhcgr2/APOE

0.520

0.032

Control females

lhcgr1/lhb1

0.415

0.004b

lhb3/APOE

0.718

<0.0001b

lhcgr1/APOE

0.281

0.031

lhcgr2/APOE

0.315

0.007b

All AD

lhcgr1/lhb1

0.465

0.017

All Control

lhcgr1/lhb1

0.352

0.006c

lhb3/APOE

0.540

<0.0001c

lhcgr1/lhb2

0.419

0.021

lhcgr2/APOE

0.265

0.044

All males

lhcgr1/lhb1

0.387

0.004a

All females

lhcgr1/lhb1

0.369

0.01a

lhcgr1/lhb2

0.301

0.047

lhcgr2/APOE

0.294

0.019

lhcgr1/lhb3

0.365

0.009a

lhb3/APOE

0.296

0.041

lhcgr1/lhb4

0.312

0.038

lhcgr1/lhb5

0.458

0.001a

lhcgr1/lhb6

0.323

0.028


a significant at the corrected α = 0.0077 level (modified FDR) for the male dataset

b significant at the corrected α = 0.0082 level (modified FDR) for the female dataset

c significant at the corrected α = 0.0081 level (modified FDR) for the total dataset.

Haasl et al. BMC Medical Genetics 2008 9:37   doi:10.1186/1471-2350-9-37

Open Data