Table 7

Known effects of the genes and polymorphisms involved in susceptibility for disturbed glucose metabolism (i.e. subjects who were IGM or who had T2DM, with the false discovery rate of 0.125), with focus on parameters that are directly related to an insulin resistance and T2DM.

Gene

Gene or Chromosomal area was implicated in:

Variation

Polymorphism was implicated in:


LPA 6q27

• The metabolic syndrome [15] which is characterised by insulin resistance

G121A

CBS 21q22.3

• Hyperhomocysteinemia [16] which, in turn, is related to diabetic nephropathy [17].

Ile278Thr

• Homocysteinuria [18].

APOB 2p24

Thr71Ile

• Interaction between ApoB (Thr71Ile) and glucose tolerance on lipid parameters [19]

SCNN1A 12p13

• Same chromosomal region as GNB3

Thr663Ala

• SCNN1A(Thr663Ala) was associated with fasting insulin levels, even after correction for BMI [20].

APOC3 11q23

• Well-known diabetes region [21].

C-641A

• APOC3(C-482T) was associated with fasting insulin [22] and in interaction with LIPC -514 C>T also on glucose tolerance [23].

APOA4 11q23

• Contained in the same region as Apo C-III

Gln360His

• Plasma glucose in women [24].

APOC3 11q23

• Well-known diabetes region [21].

C1100T

• APOC3(C-482T) was associated with fasting insulin [22] and in interaction with LIPC -514 C>T also on glucose tolerance [23]

F7 13q34

• Chromosomal area implicated in the insulin-response-to-glucose in DM2 [25].

-323 10-bp Ins/Del


van Greevenbroek et al. BMC Medical Genetics 2008 9:36   doi:10.1186/1471-2350-9-36

Open Data