Table 6

Interactions between polymorphisms in genes that are associated with IGM or T2DM at the three FDR levels.

Block Pair/Chrom.Loc. Or SNP Pair/Gene Pair

FDR = 0.125

FDR = 0.461


IGM

T2DM

IGM

T2DM


(1,5)/(1,5)

(V4:V15)/(NPPA:ADRB2)

--

--

Down

Down

(V7:V16)/(SELE:ITGA2)

--

Up

--

Up

(2,10)/(2,12)

(V8:V49)/(APOB:SCNN1A)

Down

Down

Down

Down

(V8:V50)/(APOB:GNB3)

--

Up

--

Up

(2,13)/(2,16)

(V8:V56)/(APOB:CETP)

--

Up

--

Up

(5,16)/(5,21)

(V15:V67)/(ADRB2:CBS)

--

Up

--

Up

(6,10)/(6,12)

(V18:V50)/(LPA:GNB3)

--

--

Down

Down

(V21:V48)/(TNF:SCNN1A)

--

--

Up

--

(6,11)/(6,13)

(V18:V51)/(LPA:F7)

Up

--

Up

--

(V18:V52)/(LPA:F7)

Up

--

Up

--

(6,16)/(6,21)

(V18:V67)/(LPA:CBS)

Down

Down

Down

Down

(7,12)/(7,15)

(V28:V53)/(NOS3:LIPC)

--

--

--

Up

(V30:V53)/(NOS3:LIPC)

--

--

Down

--

(8,14)/(8,17)

(V34:V62)/(LPL:ITGB3)

--

--

Up

--

(V37:V62)/(LPL:ITGB3)

--

--

--

Up

(9,11)/(11,13)

(V39:V51)/(APOA4:F7)

--

--

--

Up

(V39:V52)/(APOA4:F7)

--

--

--

Up

(V41:V51)/(APOC3:F7)

--

--

Down

Down

(V43:V51)/(APOC3:F7)

Down

Down

Down

Down

(12,13)/(15,16)

(V53:V56)/(LIPC:CETP)

--

--

Down

Down

(V53:V60)/(LIPC:CETP)

--

--

Down

--

(13,15)/(16,19)

(V56:V64)/(CETP:APOE)

--

--

--

Up

(V54:V65)/(CETP:LDLR)

--

--

--

Up

(V55:V65)/(CETP:LDLR)

--

--

Down

Down

(V56:V63)/(CETP:APOE)

--

--

Up

--

(V60 :V65)/(CETP:LDLR)

--

--

Down

--

(14,16)/(17,21)

(V62:V67)/(ITGB3:CBS)

Up

--

Up

--

(9,9)/(11,11)

(V38, V43)/(APOA4:APOC3)

--

Up

Up

Up

(V39:V40)/(APOA4:APOC3)

Up

Up

Up

Up

(V39:V42)/(APOA4:APOC3)

--

--

Up

Up

(V42:V43)/(APOC3:APOC3)

Up

--

Up

--

(10,10)/(12,12)

(V48:V49)/(SCNN1A:SCNN1A)

Up

--

Up

Up

# Pairs implicated in either IGM or T2DM or both (disturbed glucose metabolism)

14

32


The indications Up and Down are associated with IGM if they are located in the IGM columns, and with T2DM if they are located in the T2DM columns. The FDR values indicate the expected proportion of false positives among the called significantly interacting pairs in the corresponding columns respectively.

van Greevenbroek et al. BMC Medical Genetics 2008 9:36   doi:10.1186/1471-2350-9-36

Open Data