Table 3 

Polymorphisms with main effects as independent predictors of disease status. qvalue is the adjusted Pvalue using the procedure of Storey and Tibshirani [12]. 

Frequency major/minor allele (%)^{a} 
NGT + IGM (0) vs T2DM (1) 
NGT (o) vs IGM + T2DM (1) 



Exp (B) 
Pvalue (qvalue) 
Exp (B) 
Pvalue (qvalue) 



ACE 
54.2 I/39.6 D 
II 
1 (ref) 
n.a. 
1 (ref) 
n.a. 
(I/D)^{b} 
ID 
1.6 
0.14 (0.189) 
4.0 
0.001 ^{c }(0.006) 

DD 
0.9 
0.85 (0.535) 
2.4 
0.07 (0.110) 

ADRB2 
55.9 C/44.1 
CC 
1 (ref) 
n.a. 
1 (ref) 
n.a. 
(Gln27Glu)^{b} 
G 
CG 
1.8 
0.042 (0.079) 
3.9 
0.002 ^{c }(0.007) 
GG 
1.1 
0.75 (0.506) 
1.0 
1.0 (0.591) 

GNB3 
72.3 C/27.7 T 
CC 
1 (ref) 
n.a. 
1 (ref) 
n.a. 
(C825T)^{b} 
CT 
0.7 
0.18 (0.189) 
0.8 
0.6 (0.473) 

TT 
0.07 
0.0007 ^{c }(0.006) 
0.7 
0.5 (0.430) 

APOC3 
45.9 C/45.3 
CC 
1 (ref) 
n.a. 
1 (ref) 
n.a. 
(C641A)^{b} 
A 
CA 
0.6 
0.16 (0.189) 
1.1 
0.7 (0.507) 
AA 
1.4 
0.32 (0.302) 
4.1 
0.008 (0.018) 



^{a}If total of minor + major alleles < 100%, this means that there were some missing genotype data;^{b }The 4 polymorphisms that had a Pvalue < 0.05 in individual logistic analyses were entered in this logistic regression analysis simultaneously, hence the effects of these polymorphisms are adjusted for oneanother; ^{c }The expected proportion of false positives among these significant findings is 10% (FDR = 0.1). 

van Greevenbroek et al. BMC Medical Genetics 2008 9:36 doi:10.1186/14712350936 