Table 3

Polymorphisms with main effects as independent predictors of disease status. q-value is the adjusted P-value using the procedure of Storey and Tibshirani [12].

Frequency major/minor allele (%)a

NGT + IGM (0) vs T2DM (1)

NGT (o) vs IGM + T2DM (1)


Exp (B)

P-value (q-value)

Exp (B)

P-value (q-value)


ACE

54.2 I/39.6 D

II

1 (ref)

n.a.

1 (ref)

n.a.

(I/D)b

ID

1.6

0.14 (0.189)

4.0

0.001 c (0.006)

DD

0.9

0.85 (0.535)

2.4

0.07 (0.110)

ADRB2

55.9 C/44.1

CC

1 (ref)

n.a.

1 (ref)

n.a.

(Gln27Glu)b

G

CG

1.8

0.042 (0.079)

3.9

0.002 c (0.007)

GG

1.1

0.75 (0.506)

1.0

1.0 (0.591)

GNB3

72.3 C/27.7 T

CC

1 (ref)

n.a.

1 (ref)

n.a.

(C825T)b

CT

0.7

0.18 (0.189)

0.8

0.6 (0.473)

TT

0.07

0.0007 c (0.006)

0.7

0.5 (0.430)

APOC3

45.9 C/45.3

CC

1 (ref)

n.a.

1 (ref)

n.a.

(C-641A)b

A

CA

0.6

0.16 (0.189)

1.1

0.7 (0.507)

AA

1.4

0.32 (0.302)

4.1

0.008 (0.018)


aIf total of minor + major alleles < 100%, this means that there were some missing genotype data;b The 4 polymorphisms that had a P-value < 0.05 in individual logistic analyses were entered in this logistic regression analysis simultaneously, hence the effects of these polymorphisms are adjusted for one-another; c The expected proportion of false positives among these significant findings is 10% (FDR = 0.1).

van Greevenbroek et al. BMC Medical Genetics 2008 9:36   doi:10.1186/1471-2350-9-36

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