Table 3

Association of OPRM1 SNPs with response to alcohol, as measured by the Subjective High Assessment Scale-Expectations (SHAS-E) questionnaire. Significant values (p < 0.01) are highlighted in bold.

Marker

Minor

Increaser

Subjective High Assessment Scale-Expectations Item



Allele

Allele

Buzzed

Clumsy

Dizzy

Drunk

Effects

Energy

Good

Great

High

Nausea

Sleepy

Talk

Terrible

Uncom

Total


rs1799971

G

A

0.26

0.84

0.02

0.23

0.67

0.64

0.98

0.49

0.20

0.32

0.02

0.67

0.71

0.07

0.24

rs553202

A

A

0.03

0.10

0.01

0.001

0.10

0.48

0.32

0.64

0.001

0.01

0.15

0.21

0.008

0.008

0.02

rs524731

A

A

0.03

0.10

0.01

0.001

0.09

0.56

0.26

0.94

0.002

0.06

0.13

0.16

0.01

0.07

0.02

rs3778148

T

T

0.02

0.02

0.01

0.01

0.02

0.92

0.39

0.52

0.000

0.003

0.09

0.001

0.11

0.000

0.003

rs1461773

T

T

0.02

0.03

0.01

0.03

0.03

0.94

0.67

0.60

0.003

0.01

0.07

0.005

0.08

0.009

0.01

rs506247

G

G

0.40

0.95

0.51

0.06

0.91

0.58

0.63

0.55

0.35

0.44

0.47

0.48

0.07

0.83

0.64

rs563649

A

A

0.73

0.77

0.56

0.12

0.70

0.91

0.73

0.39

0.84

0.62

0.58

0.38

0.06

0.57

0.91

rs2075572

G

G

0.12

0.04

0.01

0.003

0.31

0.69

0.76

0.21

0.002

0.05

0.74

0.07

0.17

0.06

rs548646

T

T

0.01

0.01

0.001

0.02

0.02

0.12

0.77

0.91

0.06

0.02

0.04

0.03

0.33

0.02

0.005

rs648007

T

T

0.09

0.02

0.01

0.08

0.10

0.21

0.85

0.95

0.12

0.01

0.23

0.09

0.82

0.05

0.03

rs681243

A

A

0.02

0.01

0.001

0.02

0.03

0.15

0.90

0.91

0.05

0.006

0.06

0.06

0.37

0.02

0.007

rs648893

C

C

0.51

0.34

0.37

0.62

0.45

0.09

0.85

0.82

0.78

0.82

0.60

0.28

0.42

0.50

0.41

rs642489

A

A

0.43

0.25

0.31

0.55

0.40

0.09

0.83

0.80

0.79

0.71

0.45

0.28

0.50

0.55

0.36


The increaser allele for the TOTAL phenotype (i.e., the allele associated with a higher TOTAL score)

TOTAL = sum of scores reported for the first 12 SHAS-E items.

Ehlers et al. BMC Medical Genetics 2008 9:35   doi:10.1186/1471-2350-9-35

Open Data