Table 1

OPRM1 marker information, including genetic map position, location within OPRM1 and minor allele frequency.

Marker Name

Gene

Chromosomal

Functional

Alleles

MAFd

Referencese






dbSNP

Celera

Location

Location (bp)a

Location (bp)b

Minorc

Major

Indian

CEPH

China

Japan

Yoruba


rs1799971

hCV8950074

Exon 1

154,402,490

+118

G

A

0.13

0.17

0.36

0.49

0.01

1,2,3,4,5,6,7,8,9,10

rs553202

hCV809975

Intron 1

154,406,510

+4,138

A

G

0.33

0.20

nd

nd

0.41

rs524731

hCV809963

Intron 1

154,416,785

+14,413

A

C

0.32

0.18

0.04

0.02

0.05

1,3,4

rs3778148

hCV27499812

Intron 1

154,422,705

+20,333

T

G

0.08

0.14

0.04

0.02

0.04

rs1461773

hCV8949980

Intron 1

154,433,062

+30,690

T

C

0.16

0.14

0.04

0.03

0.08

rs506247

hCV27335981

Intron 1

154,437,620

+35,248

G

T

0.21

0.04

0.00

0.00

0.01

rs563649

hCV809947

Intron 1

154,449,660

+47,288

A

G

0.24

0.08

0.13

0.06

0.16

1

rs2075572

hCV1691815

Intron 2

154,453,697

+51,325

G

C

0.39

0.43

0.20

0.21

0.62

1,2,3,4

rs548646

hCV3073603

Intron 3

154,459,840

+57,468

T

C

0.18

0.33

0.07

0.13

0.46

1,3

rs648007

hCV1691794

Intron 3

154,464,304

+61,932

T

C

0.18

0.33

0.07

0.13

0.46

1

rs681243

hCV3073596

Intron 3

154,469,434

+67,062

A

G

0.18

0.24

0.06

0.14

0.43

rs648893

hCV3073587

Intron 3

154,480,321

+77,949

C

T

0.11

0.20

0.05

0.10

0.04

1,3,4,5

rs642489

hCV3073582

3' UTR

154,484,368

+81,996

A

C

0.11

0.21

0.04

0.10

0.13


abp = base-pair position on NCBI Genome Build 127.

bPosition relative to transcription start site at 154,402,372 on Chromosome 6 (NCBI Genome Build 127).

cThe allele with the lowest frequency.

dMAF = Minor Allele Frequency for the Indian tribes studied (Indians) and the reference populations CEPH (European), China, Japan, Yoruba (African). nd = no data.

eReports where each SNP has previously been genotyped: 1. Xuei et al., 2007 [100]; 2. D. Zhang et al., 2007 [98]; 3. H. Zhang et al., 2006 [99]; 4. L. Zhang et al., 2006 [101]; 5. Gelernter et al., 2007 [33]; 6. Luo et al., 2003 [97]; 7. Smith et al., 2005 [102]; 8. Crowley et al., 2003 [103]; 9. Shi et al., 2002 [104]; 10 Y. Zhang et al. 2005 [12].

Ehlers et al. BMC Medical Genetics 2008 9:35   doi:10.1186/1471-2350-9-35

Open Data