Table 2 |
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|
LAMP Analysis in GENECARD ACS families and replication in CATHGEN MI cases and controls |
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|
SNP |
LOCATION (bp) |
Alleles |
LINKAGE TEST (df = 3) |
ASSOCIATION TEST (df = 1) |
OTHER LINKED VARIANTS (df = 2) |
CATHGEN MI Logistic regression† |
CATHGEN Minor Allele Frequency |
|||||
|
Major |
Minor |
LOD |
pvalue |
LOD |
pvalue |
LOD |
pvalue |
Allele pvalue |
Allele OR (95% CI)* |
|||
|
|
||||||||||||
|
RS7514392 |
188,323,178 |
C |
g |
2.95 |
0.004 |
0.33 |
0.220 |
1.69 |
0.020 |
- |
- |
- |
|
RS10920501 |
188,328,568 |
A |
t |
2.98 |
0.003 |
0.96 |
0.040 |
2.27 |
0.005 |
0.018 |
0.612 (0.408–0.919) |
0.18 |
|
RS12142564 |
188,338,626 |
C |
t |
2.80 |
0.005 |
1.43 |
0.010 |
2.53 |
0.003 |
0.322 |
0.799 (0.508–1.257) |
0.11 |
|
RS2185836 |
188,349,217 |
A |
g |
2.89 |
0.004 |
0.76 |
0.060 |
2.82 |
0.002 |
0.273 |
0.791 (0.521–1.202) |
0.45 |
|
RS2419370 |
188,375,504 |
T |
c |
2.50 |
0.009 |
0.56 |
0.110 |
2.49 |
0.003 |
0.003 |
1.925 (1.251–2.961) |
0.44 |
|
RS2990996 |
188,411,850 |
C |
a |
3.19 |
0.002 |
0.16 |
0.400 |
3.18 |
0.001 |
0.115 |
1.441 (0.915–2.271) |
0.50 |
|
RS815343 |
188,422,256 |
C |
t |
2.97 |
0.003 |
0.34 |
0.210 |
2.31 |
0.005 |
0.005 |
0.574 (0.392–0.842) |
0.39 |
|
RS1891586 |
188,430,617 |
T |
g |
2.95 |
0.004 |
0.04 |
0.700 |
2.93 |
0.001 |
0.003 |
0.563 (0.385–0.823) |
0.23 |
|
RS9427746 |
188,438,263 |
G |
c |
2.86 |
0.004 |
0.01 |
0.810 |
2.50 |
0.003 |
0.007 |
0.587 (0.399–0.863) |
0.40 |
|
RS10920678 |
188,506,530 |
G |
a |
2.99 |
0.003 |
0.01 |
0.850 |
2.77 |
0.002 |
0.159 |
0.753 (0.508–1.117) |
0.43 |
|
RS480692 |
188,526,284 |
T |
c |
3.29 |
0.002 |
0.41 |
0.200 |
3.42 |
0.000 |
0.028 |
1.591 (1.052–2.405) |
0.43 |
|
RS12724000 |
188,618,300 |
C |
t |
2.78 |
0.005 |
0.04 |
0.660 |
2.60 |
0.003 |
0.031 |
0.645 (0.434–0.961) |
0.17 |
|
RS872177 |
188,659,068 |
T |
a |
2.93 |
0.004 |
0.05 |
0.600 |
2.90 |
0.001 |
0.188 |
0.776 (0.533–1.132) |
0.31 |
|
RS2134098 |
188,660,894 |
G |
c |
2.82 |
0.005 |
0.89 |
0.040 |
3.00 |
0.001 |
0.131 |
0.679 (0.411–1.122) |
0.08 |
|
RS10920722 |
188,694,717 |
A |
t |
2.65 |
0.007 |
0.07 |
0.600 |
2.37 |
0.004 |
0.009 |
0.589 (0.397–0.874) |
0.19 |
|
RS10920725 |
188,707,160 |
T |
c |
2.65 |
0.007 |
0.13 |
0.400 |
2.45 |
0.004 |
0.007 |
0.584 (0.394–0.865) |
0.20 |
|
RS11581737 |
188,726,896 |
G |
a |
2.87 |
0.004 |
0.18 |
0.400 |
2.76 |
0.002 |
0.031 |
0.642 (0.429–0.960) |
0.16 |
|
|
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|
*Odds Ratio (OR) calculated for minor allele, - not tested †adjusted for sex, history of hypertension, history of diabetes mellitus, body mass index, history of dyslipidemia, and smoking history |
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|
Connelly et al. BMC Medical Genetics 2008 9:33 doi:10.1186/1471-2350-9-33 |
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