Table 2

LAMP Analysis in GENECARD ACS families and replication in CATHGEN MI cases and controls

SNP

LOCATION (bp)

Alleles

LINKAGE TEST (df = 3)

ASSOCIATION TEST (df = 1)

OTHER LINKED VARIANTS (df = 2)

CATHGEN MI Logistic regression†

CATHGEN Minor Allele Frequency

Major

Minor

LOD

pvalue

LOD

pvalue

LOD

pvalue

Allele pvalue

Allele OR (95% CI)*


RS7514392

188,323,178

C

g

2.95

0.004

0.33

0.220

1.69

0.020

-

-

-

RS10920501

188,328,568

A

t

2.98

0.003

0.96

0.040

2.27

0.005

0.018

0.612 (0.408–0.919)

0.18

RS12142564

188,338,626

C

t

2.80

0.005

1.43

0.010

2.53

0.003

0.322

0.799 (0.508–1.257)

0.11

RS2185836

188,349,217

A

g

2.89

0.004

0.76

0.060

2.82

0.002

0.273

0.791 (0.521–1.202)

0.45

RS2419370

188,375,504

T

c

2.50

0.009

0.56

0.110

2.49

0.003

0.003

1.925 (1.251–2.961)

0.44

RS2990996

188,411,850

C

a

3.19

0.002

0.16

0.400

3.18

0.001

0.115

1.441 (0.915–2.271)

0.50

RS815343

188,422,256

C

t

2.97

0.003

0.34

0.210

2.31

0.005

0.005

0.574 (0.392–0.842)

0.39

RS1891586

188,430,617

T

g

2.95

0.004

0.04

0.700

2.93

0.001

0.003

0.563 (0.385–0.823)

0.23

RS9427746

188,438,263

G

c

2.86

0.004

0.01

0.810

2.50

0.003

0.007

0.587 (0.399–0.863)

0.40

RS10920678

188,506,530

G

a

2.99

0.003

0.01

0.850

2.77

0.002

0.159

0.753 (0.508–1.117)

0.43

RS480692

188,526,284

T

c

3.29

0.002

0.41

0.200

3.42

0.000

0.028

1.591 (1.052–2.405)

0.43

RS12724000

188,618,300

C

t

2.78

0.005

0.04

0.660

2.60

0.003

0.031

0.645 (0.434–0.961)

0.17

RS872177

188,659,068

T

a

2.93

0.004

0.05

0.600

2.90

0.001

0.188

0.776 (0.533–1.132)

0.31

RS2134098

188,660,894

G

c

2.82

0.005

0.89

0.040

3.00

0.001

0.131

0.679 (0.411–1.122)

0.08

RS10920722

188,694,717

A

t

2.65

0.007

0.07

0.600

2.37

0.004

0.009

0.589 (0.397–0.874)

0.19

RS10920725

188,707,160

T

c

2.65

0.007

0.13

0.400

2.45

0.004

0.007

0.584 (0.394–0.865)

0.20

RS11581737

188,726,896

G

a

2.87

0.004

0.18

0.400

2.76

0.002

0.031

0.642 (0.429–0.960)

0.16


*Odds Ratio (OR) calculated for minor allele, - not tested

†adjusted for sex, history of hypertension, history of diabetes mellitus, body mass index, history of dyslipidemia, and smoking history

Connelly et al. BMC Medical Genetics 2008 9:33   doi:10.1186/1471-2350-9-33

Open Data