FAM5C tagSNPs are associated and linked to acute coronary syndrome. 47 haplotype tagging SNPs were selected to span the length of FAM5C as well as 15 kb up and 5 kb downstream of the gene to account for potential regulatory elements. Parametric linkage (A), APL association (B) and PDT association (C) were assessed. SNPs that were linked (LOD ≥ 1) and/or associated (p ≤ 0.05) were selected for replication (markers that fall above the dashed lines, n = 16). * denotes rs10920501.
Connelly et al. BMC Medical Genetics 2008 9:33 doi:10.1186/1471-2350-9-33