Overview of the exon distribution of FH missense, renal cell cancer associated and exclusively FH deficiency related mutations. Mutations in red have been identified in cases of renal cell cancer of either type II papillary or collecting duct morphology. Variants in yellow have (as yet) been found exclusively in cases of FH deficiency. The accompanying table lists the numbers of missense variants per exon. (*These mutations are distinct at the DNA level).
Bayley et al. BMC Medical Genetics 2008 9:20 doi:10.1186/1471-2350-9-20