Figure 1.

Organisation of the synphilin-1 gene with motifs as described by Engelender et al 2000 [10] and O'Farrell et al 2002 [11]. The SNPs genotyped are located on the figure relative to exons and motifs. Ankyrin-like motifs are highlighted in yellow. The coiled-coil motif with ATP and GTP binding domain are marked in green. Motifs involved in interactions with other proteins such as alpha-synuclein [29] and Parkin [9, 30] are not known.