Table 4

Area under the receiver operating characteristic (ROC) curve with 95% confidence limits

Model

Area under the ROC curve (95% confidence limits)


All

Low risk subset

High risk subset


BRCA status

BRCAPRO

0.76 (0.70 – 0.82)

0.70 (0.57 – 0.81)

0.80 (0.73 – 0.87)

Manchester

0.68 (0.60 – 0.76)

0.57 (0.37 – 0.72)

0.73 (0.63 – 0.81)

Penn II

0.74 (0.67 – 0.80)

0.68 (0.54 – 0.79)

0.77 (0.70 – 0.83)

Myriad II

0.76 (0.71 – 0.82)

0.70 (0.59 – 0.80)

0.80 (0.72 – 0.86)

FHAT

0.74 (0.66 – 0.80)

0.66 (0.55 – 0.76)

0.83 (0.76 – 0.89)

IBIS

0.47 (0.28 – 0.69)

-

-

BOADICEA

0.74 (0.67 – 0.80)

0.68 (0.56 – 0.79)

0.77 (0.70 – 0.84)

BRCA1 status

BRCAPRO

0.80 (0.72 – 0.87)

0.8 (0.62 – 0.91)

0.81 (0.71 – 0.88)

Manchester

0.78 (0.69 – 0.86)

0.74 (0.46 – 0.93)

0.79 (0.69 – 0.88)

Penn II

0.79 (0.72 – 0.85)

0.76 (0.61 – 0.86)

0.81 (0.73 – 0.87)

COUCH

0.82 (0.75 – 0.87)

0.82 (0.65 – 0.92)

0.84 (0.75 – 0.89)

IBIS

0.43 (0.28 – 0.56)

-

-

BOADICEA

0.80 (0.72 – 0.86)

0.79 (0.61 – 0.89)

0.80 (0.71 – 0.87)

BRCA2 status

BRCAPRO

0.60 (0.50 – 0.68)

0.57 (0.42 – 0.71)

0.62 (0.48 – 0.73)

Manchester

0.60 (0.49 – 0.70)

0.56 (0.34 – 0.74)

0.63 (0.49 – 0.74)

Penn II

0.57 (0.48 – 0.65)

0.54 (0.39 – 0.69)

0.58 (0.46 – 0.69)

IBIS

0.58 (0.29 – 0.84)

-

-

BOADICEA

0.63 (0.54 – 0.73)

0.59 (0.41 – 0.76)

0.67 (0.55 – 0.77)


Panchal et al. BMC Medical Genetics 2008 9:116   doi:10.1186/1471-2350-9-116

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