Table 1

Applicability and ease of use of risk assessment models.

Calculation method

Cancers included

Inclusiveness

Family history required

Data entry


BRCAPRO

CaGene 4.3 software

Male and female breast and ovarian cancer

All individuals

1st and 2nd degree relatives

Complete pedigree data entered for affected and unaffected

Myriad II

CaGene 4.3 software

Male and female breast and ovarian cancer

All individuals

1st and 2nd degree relatives

Data searchable by established tables or data entry on CaGene 4.3 software

Couch

CaGene 4.3 software

Male and female breast and ovarian cancer

Excludes probands from families with only ovarian or male breast cancer

1st and 2nd degree relatives

Data searchable by established table or data entry on CaGene 4.3 software

Ontario Family History Assessment Tool (FHAT)

CaGene 4.3 software

Male and female breast, ovarian, colon (<50 yrs), prostate cancer (<50 yrs)

All individuals

1st and 2nd degree relatives

Data searchable by established table or data entry on CaGene 4.3 software

Manchester

Hand calculations

Male and female breast, ovarian, prostate and pancreatic cancer

Excludes Ashkenazi Jewish

1st, 2nd, and 3rd degree relatives

Scoring system

Penn II

Web-based

Male and female breast, ovarian, prostate and pancreatic cancer

Excludes probands from families with no breast cancer cases

1st, 2nd, and 3rd degree relatives

One page questionnaire

IBIS

Down-loadable software

Female breast and ovarian cancer

Includes only females unaffected by breast cancer

1st, 2nd, and 3rd degree relatives

One page questionnaire

BOADICEA

Web-based

Breast, ovarian, prostate and pancreatic cancer

All individuals

1st, 2nd, and 3rd degree relatives

Complete pedigree data entered for affected and unaffected


Panchal et al. BMC Medical Genetics 2008 9:116   doi:10.1186/1471-2350-9-116

Open Data