Table 1

Distribution of C677T genotype frequencies in the 20th century.

Frequencies by date of birth


C677T-MTHFR

Genotype-Allele

1900–1925

(n = 206)

1926–1950

(n = 320)

1951–1975

(n = 408)

1976–2000

(n = 371)

%

n

%

n

%

n

%

n


CC

0.393

81

0.394

126

0.37

151

0.299*

111

CT

0.495

102

0.488

156

0.49

200

0.461

171

TT

0.112

23

0.119

38

0.14

57

0.24**

89

C allele

0.641

264

0.638

408

0.615

502

0.53**

393

T allele

0.359

148

0.363

232

0.385

314

0.47**

349


Note: *p < 0.05; **p < 0.01 (significance values in the last quarter of the century are relative to any other quarter of the century)

Mayor-Olea et al. BMC Medical Genetics 2008 9:104   doi:10.1186/1471-2350-9-104

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