Figure 1.

Hypothetical evolution of the allelic frequencies of mthfr 677c>t polymorphism. Panel A represents the observed evolution of the allelic frequencies in the 20th century (DATA) and the hypothetical evolution predicted by the mathematical selection model (calculated fitness: s = 0.5) (PRED). Panel B represents the evolution of the allelic frequencies in the 20th century (DATA) and the hypothetical evolution based on an allelic balance dependent on folate abundance conditions.

Mayor-Olea et al. BMC Medical Genetics 2008 9:104   doi:10.1186/1471-2350-9-104
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