|
Characteristics of phenotypes studied* |
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| Eligible exam cycles |
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| Phenotype |
Na |
Description |
Offspring |
Cohort |
Adjustmentb |
Heritability |
|
|
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| ppfev1 |
1217 |
Percent predicted FEV1 for latest exam |
7, 6, 5, 3 |
19, 17, 13 |
Predicted defined by age, age2, height, % predicted adjusted for current or former smoking, pack-years, and BMI |
0.36 |
| ppfvc |
1217 |
Percent predicted FVC for latest exam |
7, 6, 5, 3 |
19, 17, 13 |
Same as ppfev1 |
0.45 |
| ppratio |
1217 |
Percent predicted FEV1/FVC for latest exam |
7, 6, 5, 3 |
19, 17, 13 |
Same as ppfev1 |
0.29 |
| ppfef |
1212 |
Percent predicted FEF25–75 for latest exam |
7, 6, 5, 3 |
19, 17, 13 |
Same as ppfev1 |
0.40 |
| ppfefrat |
1212 |
Percent predicted FEF25–75/FVC for latest exam |
7, 6, 5, 3 |
19, 17, 13 |
Same as ppfev1 |
0.41 |
| meanfev1 |
1222 |
Mean FEV1 from two exams |
3 and 5 |
5 or 6 and 13 |
age, age2, BMI, height, current or former smoking, and pack-years |
0.35 |
| meanfvc |
1222 |
Mean FVC from two exams |
3 and 5 |
5 or 6 and 13 |
Same as meanfev1 |
0.51 |
| meanratio |
1222 |
Mean FEV1/FVC from two exams |
3 and 5 |
5 or 6 and 13 |
Same as meanfev1 |
0.25 |
| fev1slope |
1097 |
Longitudinal slope of FEV1 |
7, 6, 5, 3 |
19, 17, 13 |
age, age2, height, height2, pack-years at first exam, interim pack-years, and sustained smoking |
0.10 |
| fefslope |
1059 |
Longitudinal slope of FEF25–75 |
7, 6, 5, 3 |
19, 17, 13 |
Same as fev1slope |
0.20 |
|
*Results for additional longitudinal slope phenotypes, residual from predicted phenotypes, phenotypes created from spirometry at a single exam, and phenotypes limited to smokers reporting 10 or more pack-years are available at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007 a) sample size with phenotype out of 1345 with GWA genotyping b) adjustment performed in four separate regression models by sex and Original or Offspring cohort | ||||||
Wilk et al. BMC Medical Genetics 2007 8(Suppl 1):S8 doi:10.1186/1471-2350-8-S1-S8 |
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