Table 5 |
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|
Candidate gene associations with electrocardiographic and heart rate variability traits |
||||||
|
Candidate Gene |
SNP |
Chrom |
Physical position |
Minor allele frequency |
Phenotype |
GEE P-value |
|
|
||||||
|
QT interval |
||||||
|
|
||||||
|
NOS1AP |
rs10494365 |
1 |
158815647 |
0.11 |
QT |
0.01 |
|
NOS1AP |
rs10494366 |
1 |
158817343 |
0.39 |
QT |
9.0 × 10-4 |
|
NOS1AP |
rs6683968 |
1 |
158923070 |
0.32 |
QT |
1.0 × 10-4 |
|
NOS1AP |
rs347311 |
1 |
159035565 |
0.28 |
QT |
0.01 |
|
NOS1AP |
rs945713 |
1 |
158867328 |
0.42 |
QT |
2.4 × 10-4 |
|
NOS1AP |
rs1932933 |
1 |
158849704 |
0.39 |
QT |
4.3 × 10-4 |
|
|
||||||
|
RR interval |
||||||
|
|
||||||
|
ADRA1A |
rs10503797 |
8 |
26659190 |
0.11 |
RR |
0.04 |
|
ADRB2 |
rs10515621 |
5 |
148226737 |
0.14 |
RR |
0.04 |
|
|
||||||
|
PR interval |
||||||
|
|
||||||
|
ADRA1A |
rs520180 |
8 |
26765839 |
0.25 |
PR |
0.04 |
|
|
||||||
|
LF/HF power |
||||||
|
|
||||||
|
NA |
||||||
|
|
||||||
|
Total power |
||||||
|
|
||||||
|
ADRA1B |
rs2195926 |
5 |
159255501 |
0.31 |
TP |
0.01 |
|
ADRB2 |
rs9325124 |
5 |
148229011 |
0.44 |
TP |
0.03 |
|
|
||||||
|
SDNN |
||||||
|
|
||||||
|
ADRA1A |
rs10503791 |
8 |
26611431 |
0.17 |
SDNN |
0.02 |
|
ADRA1B |
rs2195926 |
5 |
159255501 |
0.31 |
SDNN |
0.03 |
|
ADRA1A |
rs10503788 |
8 |
26611063 |
0.18 |
SDNN |
0.01 |
|
ADRA1A |
rs10503789 |
8 |
26611248 |
0.18 |
SDNN |
0.01 |
|
ADRA1A |
rs10503790 |
8 |
26611360 |
0.18 |
SDNN |
0.01 |
|
ADRA1A |
rs10503794 |
8 |
26612682 |
0.18 |
SDNN |
0.01 |
|
ADRA1A |
rs7000280 |
8 |
26611857 |
0.18 |
SDNN |
0.01 |
|
|
||||||
|
Associations with QT interval of SNPs within 60 kb of candidate genes implicated in congenital Long QT Syndrome or QT duration and with RR and PR interval, low frequency to high frequency power (LF/HF), total power, and the standard deviation of normal RR intervals (SDNN) of SNPs within 60 kb of adrenergic receptor genes at a nominal p < 0.05 are shown.* *SNPs with minor allele frequency <10%, call rate <80% or Hardy-Weinberg p-value < 0.001 were excluded. Candidate gene loci tested for association with QT interval duration include 88 SNPs within 60 kb of the following genes: KCNQ1, KCNH2, SCN5A, ANK2, KCNE1, KCNE2, KCNJ2, CACNA1C and NOS1AP. Candidate gene loci tested for association with RR, PR, LF/HF, total power, and SDNN include 35 SNPs within 60 kb of the following genes: ADRB1, ADRB2, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, and ADRA2C. |
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|
Newton-Cheh et al. BMC Medical Genetics 2007 8(Suppl 1):S7 doi:10.1186/1471-2350-8-S1-S7 |
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