Table 4 |
|||||
|
Association Results for Pre-Specified Candidate Genes |
|||||
|
Candidate gene |
Total number of SNPs* |
SNPs with p value < 0.05 |
Phenotype |
GEE p value |
FBAT p value |
|
|
|||||
|
Major CVD/Major CHD |
|||||
|
|
|||||
|
ALOX5 |
5 |
0 |
|||
|
ALOX5AP |
23 |
rs7983138 |
Major CHD |
0.011 |
0.373 |
|
rs2985183 |
Major CHD |
0.014 |
0.455 |
||
|
rs7984952 |
Major CHD |
0.015 |
0.266 |
||
|
rs117395 |
Major CHD |
0.016 |
0.568 |
||
|
rs4603405 |
Major CHD |
0.018 |
0.257 |
||
|
rs10507391 |
Major CHD |
0.028 |
0.660 |
||
|
rs10507391 |
Major CVD |
0.043 |
0.878 |
||
|
rs7995384 |
Major CHD |
0.049 |
0.967 |
||
|
GJA4 |
14 |
rs618675 |
Major CHD |
0.004 |
0.169 |
|
rs10489658 |
Major CHD |
0.004 |
0.145 |
||
|
rs618675 |
Major CVD |
0.009 |
0.464 |
||
|
rs10493062 |
Major CHD |
0.011 |
0.051 |
||
|
rs768586 |
Major CHD |
0.016 |
0.135 |
||
|
rs10489658 |
Major CVD |
0.025 |
0.237 |
||
|
rs10489656 |
Major CHD |
0.520 |
0.030 |
||
|
rs10489656 |
Major CVD |
0.538 |
0.044 |
||
|
rs2093185 |
Major CVD |
0.547 |
0.019 |
||
|
rs6686484 |
Major CHD |
1.000 |
0.031 |
||
|
LGALS2 |
1 |
0 |
|||
|
LTA |
2 |
0 |
|||
|
LTA4H |
22 |
rs10492225 |
Major CHD |
0.013 |
0.080 |
|
MEF2A |
5 |
rs2033546 |
Major CVD |
0.004 |
0.006 |
|
rs2863274 |
Major CVD |
0.006 |
0.006 |
||
|
rs2033546 |
Major CHD |
0.016 |
0.013 |
||
|
rs2863274 |
Major CHD |
0.062 |
0.021 |
||
|
MMP3 |
17 |
rs2096767 |
Major CVD |
0.028 |
0.506 |
|
rs2096767 |
Major CHD |
0.032 |
0.610 |
||
|
rs566125 |
Major CVD |
0.042 |
0.079 |
||
|
SERPINE1 |
2 |
0 |
|||
|
PCSK9 |
11 |
rs2114580 |
Major CHD |
0.010 |
0.075 |
|
rs2114580 |
Major CVD |
0.026 |
0.057 |
||
|
rs2317951 |
Major CVD |
0.076 |
0.002 |
||
|
rs2317951 |
Major CHD |
0.077 |
0.002 |
||
|
rs2317948 |
Major CHD |
0.478 |
0.029 |
||
|
rs2317948 |
Major CVD |
0.584 |
0.026 |
||
|
THBS2 |
7 |
rs911839 |
Major CVD |
0.192 |
0.035 |
|
rs911839 |
Major CHD |
0.255 |
0.032 |
||
|
THBS4 |
16 |
rs264986 |
Major CHD |
0.443 |
0.048 |
|
VAMP8 |
5 |
0 |
|||
|
|
|||||
|
Atrial fibrillation |
|||||
|
|
|||||
|
ACE |
3 |
0 |
|||
|
AGT |
13 |
rs758216 |
0.041 |
0.204 |
|
|
GJA5 |
13 |
0 |
|||
|
KCNE2 |
14 |
0 |
|||
|
KCNH2 |
6 |
0 |
|||
|
KCNJ2 |
23 |
rs10512574 |
0.140 |
0.041 |
|
|
KCNQ1 |
5 |
rs10488674 |
0.136 |
0.046 |
|
|
KCNE1 |
20 |
rs7277304 |
0.745 |
0.047 |
|
|
rs9305551 |
0.119 |
0.018 |
|||
|
|
|||||
|
Heart failure |
|||||
|
|
|||||
|
ABCC9 |
8 |
0 |
|||
|
ACTC |
15 |
rs752876 |
0.065 |
0.040 |
|
|
ADRB1 |
12 |
0 |
|||
|
ADRB2 |
18 |
rs40949 |
0.545 |
0.025 |
|
|
rs185021 |
0.947 |
0.040 |
|||
|
ADRBK1 |
0 |
- |
|||
|
ATP2A2 |
3 |
0 |
|||
|
CALML3 |
2 |
0 |
|||
|
CTF1 |
0 |
- |
|||
|
DES |
2 |
0 |
|||
|
DSP |
15 |
rs10484326 |
0.671 |
0.029 |
|
|
LDB3 |
0 |
- |
|||
|
LMNA |
5 |
0 |
|||
|
MYBPC3 |
4 |
0 |
|||
|
MYH6 |
1 |
0 |
|||
|
MYH7 |
2 |
0 |
|||
|
MYL2 |
3 |
0 |
|||
|
MYL3 |
1 |
0 |
|||
|
PLN |
16 |
rs3951042 |
0.025 |
0.083 |
|
|
rs724868 |
0.055 |
0.039 |
|||
|
rs9320660 |
0.063 |
0.034 |
|||
|
rs10484286 |
0.074 |
0.043 |
|||
|
SGCD |
37 |
0 |
|||
|
TNNC1 |
4 |
rs1133415 |
0.040 |
0.131 |
|
|
TNNI3 |
1 |
0 |
|||
|
TNNT2 |
9 |
rs832177 |
0.015 |
0.164 |
|
|
TPM1 |
7 |
rs10519186 |
0.011 |
0.085 |
|
|
rs902027 |
0.152 |
0.011 |
|||
|
TTN |
13 |
rs10497521 |
0.705 |
0.030 |
|
|
VCL |
3 |
0 |
|||
|
|
|||||
|
*Includes all SNPs within 200 kb upstream of start to 200 kb downstream of end of gene, with genotype call rate ≥0.8; minor allele frequency ≥0.1; HWE p ≥ 0.001. Data are sorted by GEE additive genetic effects model with FBAT results provided alongside. |
|||||
|
Larson et al. BMC Medical Genetics 2007 8(Suppl 1):S5 doi:10.1186/1471-2350-8-S1-S5 |
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