Table 4 |
||||||||
|
All Significant SNP Associations with Selected Longevity Candidate Genes* (FBAT or GEE p-value < 0.01) |
||||||||
|
Trait |
Gene |
SNP |
Chr |
Physical Position |
FBAT p-value |
GEE p-value |
SNP function |
SNP position relative to gene (up to 60 kb) |
|
|
||||||||
|
Age at death |
FOXO1a |
rs4943794 |
13 |
40,071,408 |
0.068 |
0.00028 |
Intron |
in |
|
rs10507486 |
13 |
40,084,501 |
0.043 |
0.00013 |
Intron |
in |
||
|
GAPDH† |
rs4764600 |
12 |
6,472,241 |
0.833 |
0.005 |
Locus/intron |
near |
|
|
KL |
rs683907 |
13 |
32,522,175 |
0.009 |
0.507 |
Intron |
in |
|
|
rs687045 |
13 |
32,522,889 |
0.007 |
0.712 |
Intron |
in |
||
|
LEPR |
rs1475398 |
1 |
65,695,278 |
0.069 |
0.005 |
Untranslated |
in |
|
|
rs1343981 |
1 |
65,757,349 |
0.031 |
0.006 |
Intron |
in |
||
|
rs10493379 |
1 |
65,757,948 |
0.015 |
0.004 |
Intron |
in |
||
|
rs2154380 |
1 |
65,769,462 |
0.004 |
0.003 |
Intron |
in |
||
|
rs6669117 |
1 |
65,773,093 |
0.050 |
0.007 |
Intron |
in |
||
|
PON1 |
rs2374983 |
7 |
94,516,375 |
0.980 |
0.006 |
Intron |
near |
|
|
PSEN1 |
rs362356 |
14 |
72,708,382 |
0.005 |
0.130 |
Intron |
in |
|
|
SOD2 |
rs911847 |
6 |
160,039,379 |
0.358 |
0.005 |
Unknown |
near |
|
|
WRN‡ |
rs2543600 |
8 |
30,969,282 |
0.182 |
4.2 × 10-6 |
Unknown |
near |
|
|
Morbidity-free survival at age 65 |
GHR |
rs719756 |
5 |
42,761,386 |
0.003 |
0.676 |
Unknown |
near |
|
LEPR |
rs1171278 |
1 |
65,700,167 |
0.042 |
0.003 |
Untranslated |
in |
|
|
rs3790426 |
1 |
65,755,040 |
0.460 |
0.002 |
Intron |
in |
||
|
MORF4L1 |
rs1383636 |
15 |
76,893,275 |
0.458 |
0.007 |
Unknown |
near |
|
|
PON1 |
rs2374983 |
7 |
94,516,375 |
0.727 |
0.007 |
Intron |
near |
|
|
rs854523 |
7 |
94,542,884 |
0.850 |
0.007 |
Intron |
in |
||
|
PTH |
rs10500784 |
11 |
13,530,401 |
0.010 |
0.990 |
Unknown |
near |
|
|
WRN‡ |
rs2725369 |
8 |
30,970,566 |
0.113 |
0.003 |
Unknown |
near |
|
|
Biologic Age by OSS |
FOXO1a |
rs1923249 |
13 |
40,041,881 |
0.006 |
0.004 |
Intron |
in |
|
rs4943794 |
13 |
40,071,408 |
0.009 |
0.016 |
Intron |
in |
||
|
HSPA9 |
rs256014 |
5 |
137,930,983 |
0.101 |
0.005 |
Intron |
in |
|
|
LASS6 |
rs1002666 |
2 |
169,303,525 |
0.001 |
0.008 |
Intron |
in |
|
|
SOD2 |
rs911847 |
6 |
160,039,379 |
0.024 |
0.009 |
Unknown |
near |
|
|
TLR4 |
rs1927914 |
9 |
117,544,279 |
0.007 |
0.401 |
Locus |
near |
|
|
Walking speed |
ESR1 |
rs9322361 |
6 |
152,551,257 |
0.124 |
0.0089 |
Intron |
in |
|
LASS6 |
rs6433083 |
2 |
169,324,821 |
0.232 |
0.006 |
Intron |
in |
|
|
NR3C1 |
rs2918418 |
5 |
142,703,566 |
0.005 |
0.081 |
Intron |
in |
|
|
rs10515522 |
5 |
142,738,587 |
0.004 |
0.084 |
Intron |
in |
||
|
SOD1 |
rs2833485 |
21 |
32,000,796 |
0.008 |
0.507 |
Locus/intron |
in |
|
|
TERF2 |
rs728546 |
16 |
68,013,029 |
0.0045 |
0.533 |
Unknown |
near |
|
|
FASLG |
rs6700734 |
1 |
169,362,468 |
0.003 |
0.029 |
Intron |
in |
|
|
|
||||||||
|
*79 genes identified from NCBI, SAGE ke, and GenAge databases; 12 genes with no SNPs on 100K chip; 67 genes with 1–45 SNPs on 100K chip; LGV1 2036 SNPs on 100K chip, results for this region available on the web †The most strongly associated SNP near GAPDH is actually closer to MRPL51 ‡The most strongly associated SNP near WRN is actually closer to PURG |
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|
Lunetta et al. BMC Medical Genetics 2007 8(Suppl 1):S13 doi:10.1186/1471-2350-8-S1-S13 |
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