Table 4

Haplotype analysis of the association between MAPT and Creutzfeldt-Jakob disease
Haplotype
 Alleles
 Frequency
 P-value
 Frequency
 P-value




rs242559
 rs242557
 rs3785883
 rs2471738
 H1/H2
 rs7521
 Controls
 sCJD
UK sCJD
 UK vCJD
H1e
 A
 G
 G
 C
 G
 A
 0.25
 0.26
 ref
 0.24
 0.2
 0.51
H2a
 C
 G
 G
 C
 A
 G
 0.23
 0.22
 0.64
 0.28
 0.31
 ref
H1c
 A
 A
 G
 T
 G
 G
 0.12
 0.15
 0.46
 0.16
 0.1
 0.4
H1d
 A
 A
 G
 C
 G
 A
 0.13
 0.1
 0.08
 0.07
 0.16
 0.18
H1f
 A
 G
 A
 C
 G
 G
 0.05
 0.05
 0.88
 0.08
 0.02
 0.04
H1g
 A
 A
 G
 C
 G
 G
 0.05
 0.05
 0.91
 _
 _
 _
H1h
 A
 G
 A
 C
 G
 A
 0.04
 0.04
 0.64
 _
 _
 _
H1i
 A
 A
 A
 C
 G
 A
 0.03
 0.03
 0.68
 _
 _
 _
H1j
 A
 A
 A
 T
 G
 G
 0.03
 0.02
 0.45
 0.01
 0.07
 0.01
H1b
 A
 G
 G
 C
 G
 G
 0.02
 0.02
 0.55
 _
 _
 _

P-values are not corrected for multiple testing

Included all haplotypes present in both sCJD and vCJD

sCJD: sporadic Creutzfeldt Jakob disease

vCJD:variant Creutzfeldt Jakob disease

Sánchez-Juan et al. BMC Medical Genetics 2007 8:77   doi:10.1186/1471-2350-8-77