Figure 2.

Linkage disequilibrium (LD) map of the PITX1.gene. Thirteen SNP markers within the 6.5 kb of genomic sequence span the 5' and 3' UTRs of PITX1. Pair-wise LD among SNPs was investigated using D'. Haplotype blocks were determined by identifying the first and last markers in a block, which are in strong LD with all intermediate markers. The structure and position of the PITX1 gene, the positions of the 5 SNPs from the first step genotyping and the 9 SNPS from the second step genotyping are indicated (SNP markers in bold), respectively. LD, linkage disequilibrium; SNP, small nucleotide polymorphism; UTR, 5'-untranslated regions.