Figure 1.

Genomic organization of the linkage region on chromosome 5q31 and haplotype heat-map of PITX1. A) Five clones in the region showed elevated identity-by-descent sharing values. The highest p-value was observed for clone FE0DBACA4ZA08 (p = 6.40 * 10^-7, position (built 34) = chr5:134.467.793 – 134.639.841). Orientation of gene transcription is indicated by arrows. The bottom panel shows the exon-intron structure of the PITX1 gene. Two transcripts have been described for the gene, which make use of the same start and stop codons but differ in their respective 5' and 3' UTR regions.