Additional file 7.

Linkage disequilibrium (LD) plot across the prolactin receptor (PRLR) locus for African-Americans. The horizontal black line depicts the 210-kilobase region of chromosome (chr) 5 analyzed in our multiethnic panel. The PRLR gene is shown in grey (RefSeq gene = completed genes from the human genome assembly). Alternative first exons are shown in black below the gene: hE13, hE1N1, hE1N2, hE1N3, hE1N4, and hE1N5. The LD plot, presented at the bottom of the figures, is based on the measure of D'. Each diamond indicates the pairwise magnitude of LD, with dark grey indicating strong LD (D' > 0.8) and a logarithm of odds score of greater than 2.0. Single nucleotide polymorphisms (SNPs) < 5% for this ethnic group not shown. (Figure prepared with LocusView, Broad Institute, Cambridge, MA, unpublished software by T. Petryshen, A. Kirby, and M. Ainscow [61]).

Format: PNG Size: 413KB Download file

Lee et al. BMC Medical Genetics 2007 8:72   doi:10.1186/1471-2350-8-72