Additional file 4.

Linkage disequilibrium (LD) plot across the prolactin (PRL) locus for Japanese-Americans. The horizontal black line depicts the 59-kilobase region of chromosome (chr) 6 analyzed in our multiethnic panel. The PRL gene is shown in grey (RefSeq gene = completed genes from the human genome assembly). Alternative exon 1a (associated with the distal extra-pituitary promoter region) lies 5.8 kb upstream of exon 1 (associated with the pituitary promoter region). The LD plot, presented at the bottom of the figures, is based on the measure of D'. Each diamond indicates the pairwise magnitude of LD, with dark grey indicating strong LD (D' > 0.8) and a logarithm of odds score of greater than 2.0. Single nucleotide polymorphisms (SNPs) < 5% for this ethnic group not shown. (Figure prepared with LocusView, Broad Institute, Cambridge, MA, unpublished software by T. Petryshen, A. Kirby, and M. Ainscow [61]).

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Lee et al. BMC Medical Genetics 2007 8:72   doi:10.1186/1471-2350-8-72