|
Association tests between 6 SNPs and premature heart disease performed using the Transmission Disequilibrium Test/sibling Transmission Disequilibrium Test (TDT/S-TDT) |
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| SNP name |
Coding variant |
Allele |
Number of informative families |
W1 |
Expected(W) |
Variance(W) |
P-value |
|
|
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| rs 800292 |
I62V |
CT |
218 |
289 |
288.7 |
60.4 |
0.97 |
| rs 1061170 |
Y402H |
CT |
323 |
300 |
294.9 |
107.0 |
0.62 |
| rs 2274700 |
A473A |
AG |
203 |
132 |
128.2 |
57.0 |
0.62 |
| rs 3753396 |
Q672Q |
AG |
218 |
314 |
310.7 |
61.1 |
0.67 |
| rs 419137 |
AC |
181 |
253 |
254.0 |
48.4 |
0.89 |
|
| rs 2284664 |
AG |
216 |
142 |
141.3 |
59.9 |
0.93 |
|
|
1 W = X+Y where X is the number of transmissions of the first-mentioned allele from heterozygote parents to affected siblings (TDT) and Y is the number of occurrences of the first-mentioned allele in affected sibs in remaining informative families (S-TDT). The 6 SNPs are arranged in an order according to their positions in the CFH gene. | |||||||
Meng et al. BMC Medical Genetics 2007 8:62 doi:10.1186/1471-2350-8-62 |
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