Table 3

Association tests between 6 SNPs and premature heart disease performed using the Transmission Disequilibrium Test/sibling Transmission Disequilibrium Test (TDT/S-TDT)

SNP name

Coding variant

Allele

Number of informative families

W1

Expected(W)

Variance(W)

P-value


rs 800292

I62V

CT

218

289

288.7

60.4

0.97

rs 1061170

Y402H

CT

323

300

294.9

107.0

0.62

rs 2274700

A473A

AG

203

132

128.2

57.0

0.62

rs 3753396

Q672Q

AG

218

314

310.7

61.1

0.67

rs 419137

AC

181

253

254.0

48.4

0.89

rs 2284664

AG

216

142

141.3

59.9

0.93


1 W = X+Y where X is the number of transmissions of the first-mentioned allele from heterozygote parents to affected siblings (TDT) and Y is the number of occurrences of the first-mentioned allele in affected sibs in remaining informative families (S-TDT).

The 6 SNPs are arranged in an order according to their positions in the CFH gene.

Meng et al. BMC Medical Genetics 2007 8:62   doi:10.1186/1471-2350-8-62

Open Data