Open Access Research article

Genetic variants of Complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population

Weihua Meng1, Anne Hughes1, Chris C Patterson1, Christine Belton1, Muhammad S Kamaruddin2, Paul G Horan2, Frank Kee1 and Pascal P McKeown123*

Author Affiliations

1 Centre for Clinical and Population Sciences, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland, UK

2 Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK

3 Department of Medicine, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland, UK

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BMC Medical Genetics 2007, 8:62  doi:10.1186/1471-2350-8-62

Published: 18 September 2007

Abstract

Background

The complement factor H (CFH) gene has been recently confirmed to play an essential role in the development of age-related macular degeneration (AMD). There are conflicting reports of its role in coronary heart disease. This study was designed to investigate if, using a family-based approach, there was an association between genetic variants of the CFH gene and risk of early-onset coronary heart disease.

Methods

We evaluated 6 SNPs and 5 common haplotypes in the CFH gene amongst 1494 individuals in 580 Irish families with at least one member prematurely affected with coronary heart disease. Genotypes were determined by multiplex SNaPshot technology.

Results

Using the TDT/S-TDT test, we did not find an association between any of the individual SNPs or any of the 5 haplotypes and early-onset coronary heart disease.

Conclusion

In this family-based study, we found no association between the CFH gene and early-onset coronary heart disease.