Table 2

Obesity and T2D case control analyses for SGNE1 SNPs. OR: odds ratio. ORs and p values are for allele frequencies comparisons. χ² test and the p values were computed with De Finetti program [17]. All obese cases are the pooled sample of obese children and severely obese adults.

Genotype Frequencies

Allele Frequencies

OR [95%CI] (p value)

-1839 A>T rs13850

AA

AT

TT

A

T

Obese Children

384

128

21

0.84

0.16

1.10 [0.90–1.34] (0.335)

Severely obese adults

475

164

20

0.85

0.15

1.06 [0.88–1.28] (0.515)

All obese

859

292

41

0.84

0.16

1.08 [0.92–1.26] (0.327)

Type 2 Diabetes

777

306

20

0.84

0.16

1.08 [0.92–1.26] (0.339)

Controls

950

335

25

0.85

0.15

-1,701 A>G rs11635997

AA

AG

GG

A

G

Obese Children

191

267

90

0.59

0.41

1.14 [0.98–1.31] (0.078)

Severely obese adults

266

322

101

0.62

0.38

1.01 [0.88–1.16] (0.837)

All obese

457

589

191

0.61

0.39

1.07 [0.95–1.20] (0.255)

Type 2 Diabetes

554

722

208

0.62

0.38

1.03 [0.92–1.15] (0.619)

Controls

496

618

178

0.62

0.38

-706 C>G rs12595007

CC

CG

GG

C

G

Obese Children

384

111

10

0.87

0.13

0.83 [0.67–1.10] (0.081)

Severely obese adults

439

170

10

0.85

0.15

1.01 [0.84–1.21] (0.930)

All obese

823

281

20

0.86

0.14

0.92 [0.79–1.26] (0.343)

Type 2 Diabetes

976

352

21

0.85

0.15

0.95 [0.82–1.10] (0.511)

Controls

970

357

28

0.85

0.15

-304 A>G

AA

AG

GG

A

G

Obese Children

445

59

5

0.93

0.07

1.13 [0.84–1.51] (0.402)

Severely obese adults

587

91

2

0.93

0.07

1.17 [0.90–1.52] (0.240)

All obese

1032

150

7

0.93

0.07

1.15 [0.92–1.44] (0.210)

Type 2 Diabetes

1187

145

3

0.94

0.06

0.93 [0.74–1.17] (0.555)

Controls

1194

151

6

0.94

0.06

IVS3 -13,276 T>C rs1406387

TT

TC

CC

T

C

Obese Children

218

239

93

0.61

0.39

1.00 [0.86–1.15] (0.996)

Severely obese adults

243

340

102

0.60

0.40

1.05 [0.91–1.19] (0.510)

All obese

461

579

195

0.61

0.39

1.02 [0.92–1.14] (0.664)

Type 2 Diabetes

552

729

251

0.60

0.40

1.06 [0.96–1.18] (0.234)

Controls

499

666

191

0.61

0.39

IVS3-9,221 A>G rs8037112

AA

AG

GG

A

G

Obese Children

219

233

91

0.62

0.38

0.96 [0.83–1.11] (0.606)

Severely obese adults

260

322

95

0.62

0.38

0.95 [0.82–1.08] (0.422)

All obese

479

555

186

0.62

0.38

0.97 [0.85–1.07] (0.408)

Type 2 Diabetes

525

669

209

0.61

0.39

0.98 [0.88–1.10] (0.774)

Controls

481

666

190

0.61

0.39

IVS3 -3,045 A>C rs7170561

AA

AC

CC

A

C

Obese Children

248

211

66

0.67

0.33

1.04 [0.89–1.21] (0.621)

Severely obese adults

318

282

79

0.68

0.32

1.03 [0.89–1.18] (0.541)

All obese

566

493

145

0.67

0.33

1.03 [0.92–1.16] (0.598)

Type 2 Diabetes

627

603

155

0.67

0.33

1.05 [0.94–1.18] (0.372)

Controls

611

586

129

0.68

0.32

IVS3-2,058 A>Grs28688414

AA

AG

GG

A

G

Obese Children

307

184

33

0.76

0.24

1.00 [0.85–1.19] (0.959)

Severely obese adults

394

241

44

0.76

0.24

1.02 [0.88–1.19] (0.750)

All obese

701

425

77

0.76

0.24

1.01 [0.89–1.15] (0.809)

Type 2 Diabetes

803

480

94

0.76

0.24

1.03 [0.91–1.16] (0.678)

Controls

778

499

71

0.76

0.24

IVS3 +823 A>T rs12442397

AA

AT

TT

A

T

Obese Children

249

215

70

0.67

0.33

1.14 [0.98–1.32] (0.094)

Severely obese adults

320

293

64

0.69

0.31

1.03 [0.89–1.18] (0.670)

All obese

569

508

134

0.68

0.32

1.08 [0.96–0.1.21] (0.217)

Type 2 Diabetes

720

619

166

0.68

0.32

1.05 [0.94–1.18] (0.347)

Controls

642

583

117

0.70

0.30

IVS3 +881 A>C rs12438604

AA

AC

CC

A

C

Obese Children

323

184

35

0.77

0.23

1.16 [0.98–1.38] (0.073)

Severely obese adults

416

238

27

0.79

0.21

1.04 [0.89–1.22] (0.630)

All obese

739

422

62

0.78

0.22

1.09 [0.96–1.25] (0.181)

Type 2 Diabetes

903

463

81

0.78

0.22

1.05 [0.92–1.19] (0.459)

Controls

842

450

55

0.79

0.21

IVS4 +2,853 A>T rs11638903

AA

AT

TT

A

T

Obese Children

286

199

61

0.71

0.29

0.98 [0.84–1.15] (0.822)

Severely obese adults

335

291

56

0.70

0.30

0.99 [0.86–1.14] (0.885)

All obese

621

490

117

0.71

0.29

0.98 [0.87–1.11] (0.822)

Type 2 Diabetes

703

615

128

0.70

0.30

1.02 [0.91–1.14] (0.772)

Controls

657

588

109

0.70

0.30

IVS4 +1,514 G>C rs12592208

GG

GC

CC

G

C

Obese Children

281

195

65

0.70

0.30

0.96 [0.82–1.11] (0.591)

Severely obese adults

313

289

58

0.69

0.31

0.99 [0.85–1.14] (0.873)

All obese

594

484

123

0.70

0.30

0.97 [0.86–1.10] (0.678)

Type 2 Diabetes

716

647

139

0.69

0.31

0.99 [0.89–1.11] (0.911)

Controls

616

579

116

0.69

0.31

Bouatia-Naji et al. BMC Medical Genetics 2007 8:44   doi:10.1186/1471-2350-8-44