Table 4

TPH2 alleles in autistic patients with(+) or without (-) motor stereotypies (MS) or verbal stereotypies (VS).

SNP

Allele

AUTISTIC PATIENTS

CONTROLS*


M.S. PRESENT

M.S. ABSENT

V.S. PRESENT

V.S. ABSENT


rs4570625

G

104/148 (70.3%)

37/54 (68.5%)

60/82 (73.2%)

74/110 (67.3%)

206/268 (76.9%)

T

44/148 (29.7%)

17/54 (31.5%)

22/82 (26.8%)

36/110 (32.7%)

62/268 (23.1%)

statistics

M.S. + vs -: χ2 = 0.06, 1 df, P = 0.81

V.S. + vs -: χ2 = 0.78 1 df, P = 0.38

M.S. + vs Controls: χ2 = 2.18, 1 df, P = 0.14

V.S. + vs Controls:χ2 = 0.47, 1 df, P = 0.49

M.S. - vs Controls: χ2 = 1.69, 1 df, P = 0.19

V.S. - vs Controls:χ2 = 3.74, 1 df, P = 0.053


rs4565946

C

79/153 (51.6%)

34/64 (53.1%)

51/95 (53.7%)

58/113 (51.3%)

156/268 (58.2%)

T

74/153 (48.4%)

30/64 (46.9%)

44/95 (46.3%)

55/113 (48.7%)

112/268 (41.8%)

statistics

M.S. + vs -: χ2 = 0.04 1 df, P = 0.84

V.S. + vs -: χ2 = 0.11, 1 df, P = 0.73

M.S. + vs Controls: χ2 = 1.71, 1 df, P = 0.19

V.S. + vs Controls: χ2 = 0.59, 1 df, P = 0.44

M.S. - vs Controls: χ2 = 0.55, 1 df, P = 0.46

V.S. - vs Controls: χ2 = 1.53, 1 df, P = 0.22


Haplotypes

Estimated Frequency in M.S. and/or V.S. present

Estimated Frequency in M.S. and/or V.S. absent

G-C

0.3271

0.3065

G-T

0.458

0.4516

T-C

0.201

0.2419

T-T

0.014

-


Likelihood ratio test: null = -232.5, alternative = -232, LRS = 1.034, 3 df, P = 0.59


*Allelic frequencies for controls are from ref 13.

Sacco et al. BMC Medical Genetics 2007 8:11   doi:10.1186/1471-2350-8-11

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