Table 3

Serotonin blood levels, urinary peptide excretion rates, and head circumference by TPH2 and GLO1 genotypes. *

TPH2

AUTISTIC PATIENTS – RS4570625

AUTISTIC PATIENTS – RS4565946


GG

GT

TT

Statistics

CC

CT

TT

Statistics


Serotonin Blood Levels (ng/ml)

352.4 ± 35.7 (90)

293.8 ± 40.7 (39)

261.2 ± 57.0 (6)

F = 0.642 (2,132 df), P = 0.53

377.4 ± 64.9 (42)

328.2 ± 33.2 (58)

289.1 ± 42.1 (32)

F = 0.742 (2,129 df), P = 0.48

Urinary Peptides (AUC in μm2)

309.5 ± 122 (80)

297.5 ± 97.5 (42)

332.0 (2)

K-W χ2 = 3.340, 2 df, P = 0.19

306.0 ± 127.5 (33)

298.0 ± 86.5 (57)

296.0 ± 150 (32)

K-W χ2 = 0.172, 2 df, P = 0.92

Head Circumference (percentile)

82.5 ± 23.7 (97)

82.5 ± 17.5 (57)

50.0 ± 24 (6)

K-W χ2 = 2.324, 2 df, P = 0.31

75.0 ± 23.7 (42)

75.0 ± 23.7 (72)

90.0 ± 23.7 (42)

K-W χ2 = 0.958, 2 df, P = 0.62


GLO1

AUTISTIC PATIENTS

UNAFFECTED SIBLINGS


AA

AC

CC

Statistics

AA

AC

CC

Statistics


Serotonin Blood Levels (ng/ml)

213.2 ± 22.5 (49)

208.5 ± 11.7 (76)

244.3 ± 24.2 (29)

F = 0.857 (2,153 df), P = 0.43

201.0 ± 33.5 (22)

189.8 ± 29.4 (18)

177.8 ± 20.9 (10)

F = 0.111 (2,49 df), P = 0.90

Urinary Peptides (AUC in μm2)

324.0 ± 110 (55)

313.0 ± 120 (85)

319.0 ± 132 (37)

K-W χ2 = 0.711, 2 df, P = 0.70

212.5 ± 65 (26)

196.0 ± 98 (25)

290.0 ± 146.5 (15)

K-W χ2 = 1.363, 2 df, P = 0.51

Head Circumference (percentile)

82.5 ± 17.5 (63)

82.5 ± 23.8 (99)

75.0 ± 33.2 (40)

K-W χ2 = 1.325, 2 df, P = 0.52

86.3 ± 19.1 (22)

82.5 ± 23.8 (22)

82.5 ± 31.6 (10)

K-W χ2 = 0.788, 2 df, P = 0.67


* Data are expressed as mean ± S.E.M. for serotonin blood levels, and median ± semi-interquartilic range for amounts of urinary peptides and head circumference; 2-tail P-values are reported. Sample sizes are shown in italics; K-W = Kruskal-Wallis non-parametric ANOVA.

Sacco et al. BMC Medical Genetics 2007 8:11   doi:10.1186/1471-2350-8-11

Open Data