Table 2

TDT and FBAT analyses of SNPs rs4570625 and rs4565946, and relative haplotypes at the TPH2 locus.*

TDT

TPH2 – RS4570625

TPH2 – rs4565946

HAPLOTYPES RS4570625-RS4565946

N = 224 complete trios

N = 219 complete trios

Haplotype

T

NT

χ2 (1df)

P-value


G Transmitted

88

χ2 = 1.21(1 df), P = 0.27

C Transmitted

107

χ2 = 0.57(1 df), P = 0.45

G-C

73

72

0.01

0.92

T Transmitted

77

T Transmitted

116

G-T

87

74

1.05

0.31

T-C

51

63

1.26

0.26

T-T

1

3

1.00

0.32


FBAT

Allele

N. of families

S

E(S)

Var(S)

Z

P


rs4570625

G

136

194.000

188.000

42.000

0.926

0.35

T

136

84.000

90.000

42.000

-0.926

rs4565946

C

166

161.000

165.500

57.750

-0.592

0.55

T

166

183.000

178.500

57.750

0.592

Haplotypes (Estimated Freq)

G-T (0.486)

160.9

195.112

190.637

56.686

0.594

0.55

G-C (0.296)

154.0

127.888

126.863

48.312

0.147

0.88

T-C (0.211)

125.4

78.112

83.137

39.218

-0.802

0.42

T-T (0.008)

6.7

-

-

-

-

-


*FBAT analyses are performed under an additive model [29,30]. P-values are rounded to the second digit.

Sacco et al. BMC Medical Genetics 2007 8:11   doi:10.1186/1471-2350-8-11

Open Data