Table 1

Chromosome Locations

CHR

Trait

LOC (cM)

LOD

Nearest Marker

Supporting References (phenotype)

1

Persistent Tob Use

75

1.3

D1S2652

1

Regular Tob Use

175

1.2

D1S196

Bierut et al. 2004 (Alc dep & smoking)

4

Persistent Tob Use

100

1.5

D4S2460

Straub et al. 1999, Duggirala et al. 1999 (Tob), Long et al. 1998 (Alc dep), Reich et al. 1998 (Alc dep), Saccone et al. 2003 (Max drinks), Ehlers et al. 2004b(Alc drink severity)

6

Regular Tob Use

50–75

2.0

D6S1575

Ehlers et al. 2004b (Alc withdrawal), Bergen et al. 1999 (Smoking)

7

Regular Tob Use

140

1.5

D7S640

Gelernter et al. 2004

8

Regular Tob Use

110

2.0

D8S1762

13

Regular Tob Use

20

1.3

D13S289

Saccone et al. (2003)

22

Regular Tob Use

40–50

1.3

D22S274

Saccone et al. (2003)

Abbreviations: CHR (chromosome number), LOC (location), Tob Use (tobacco usage), Alc dep (Alcohol dependence), Tob (Tobacco use phenotypes), Max drinks (maximum number of drinks consumed in a 24 hr period), Alc withdrawal (alcohol withdrawal severity phenotype) Alc drink severity (severity of drinking symptoms from DSM-III-R alcohol dependence).

Ehlers and Wilhelmsen BMC Medical Genetics 2006 7:9   doi:10.1186/1471-2350-7-9