Genome-wide significance for a modifier of age at neurological onset in Huntington's Disease at 6q23-24: the HD MAPS study

Jian-Liang Li^1,2,3 , Michael R Hayden⁴ , Simon C Warby⁴ , Alexandra Durr⁵ , Patrick J Morrison^6,7 , Martha Nance⁸ , Christopher A Ross^9,10,11 , Russell L Margolis^9,10 , Adam Rosenblatt⁹ , Ferdinando Squitieri¹² , Luigi Frati¹³ , Estrella Gómez-Tortosa¹⁴ , Carmen Ayuso García¹⁴ , Oksana Suchowersky¹⁵ , Mary Lou Klimek¹⁵ , Ronald JA Trent¹⁶ , Elizabeth McCusker¹⁷ , Andrea Novelletto¹⁸ , Marina Frontali¹⁹ , Jane S Paulsen²⁰ , Randi Jones²¹ , Tetsuo Ashizawa²² , Alice Lazzarini^23,24 , Vanessa C Wheeler²⁵ , Ranjana Prakash¹ , Gang Xu^1,2 , Luc Djoussé²⁶ , Jayalakshmi Srinidhi Mysore²⁵ , Tammy Gillis²⁵ , Michael Hakky²⁵ , L Adrienne Cupples²⁷ , Marie H Saint-Hilaire¹ , Jang-Ho J Cha²⁸ , Steven M Hersch²⁸ , John B Penney²⁸ , Madaline B Harrison²⁹ , Susan L Perlman³⁰ , Andrea Zanko³¹ , Ruth K Abramson³² , Anthony J Lechich³³ , Ayana Duckett³³ , Karen Marder³³ , P Michael Conneally³⁴ , James F Gusella^25,35 , Marcy E MacDonald²⁵ and Richard H Myers^1,2

¹Department of Neurology, Boston University School of Medicine, Boston, MA, USA

²Bioinformatics Program, Boston University, Boston, MA, USA

³Department of Biological Technologies, Wyeth Research, Cambridge, MA, USA

⁴Centre for Molecular Medicine & Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

⁵INSERM U679, Hôpital de la Salpêtrière, Paris, France

⁶Department of Medical Genetics, Belfast City Hospital, Belfast, UK

⁷School of Biomedical Science, University of Ulster, Coleraine, UK

⁸Department of Neurology, Hennepin County Medical Center, Minneapolis, Minnesota, USA

⁹Departments of Psychiatry and Neurology, John Hopkins University, Baltimore, Maryland, USA

¹⁰Program in Cellular and Molecular Medicine, John Hopkins University, Baltimore, Maryland, USA

¹¹Department of Neuroscience, John Hopkins University, Baltimore, Maryland, USA

¹²Neurogenetics Unit, IRCCS Neuromed, Pozzilli, Italy

¹³Dept of Experimental Medicine and Pathology, University "La Sapienza" of Rome, Rome, Italy

¹⁴Servicio de Neurología y Genética, Fundación Jiménez Díaz, Madrid, Spain

¹⁵Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta, Canada

¹⁶Department of Medicine, University of Sydney, Sydney, Australia

¹⁷Neurology Department, Westmead Hospital, Sydney, Australia

¹⁸Department of Biology, University "Tor Vergata", 00133 Rome, Italy

¹⁹Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy

²⁰Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA

²¹Neurology Department, Emory University, Atlanta, Georgia, USA

²²Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA

²³Department of Neurology, Robert Wood Johnson school of Medicine and Dentistry of New Jersey, USA

²⁴Novartis Pharmaceuticals, New Brunswick, NJ, USA

²⁵Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA

²⁶Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA

²⁷Department of Biostatistics, School of Public Health, Boston University, Boston MA, USA

²⁸Department of Neurology, Massachusetts General Hospital, Boston, MA, USA

²⁹Health Sciences Center, University of Virginia, Charlottesville, Virginia, USA

³⁰Department of Neurology, University of California at Los Angeles, California, USA

³¹Division of Medical Genetics, UCSF, San Francisco, California, USA

³²WMS Hall Psychiatric Institute, Columbia, South Carolina, USA

³³Department of Neurology, Columbia College of Physicians, New York, NY, USA

³⁴Department of Genetics, Indiana University School of Medicine, Indianapolis, IN, USA

³⁵Department of Genetics, Harvard Medical School, Boston, MA, USA